骨细胞相关标志物在骨质疏松症和脆性骨折预测中的研究进展  

Research progress of the osteocyte-related biomarkers in predicting osteoporosis and fragility fractures

作　　者：李仕伟[1] 王柏灵 石成 孙中洋 LI Shiwei;WANG Boling;SHI Cheng;SUN Zhongyang(Department of Nuclear Medicine,Nanjing First Hospital,Nanjing Medical UniversityNanjing First Hospital,Jiangsu Province,Nanjing210019,China;Department of Clinical Laboratory,Nanjing Yuhua HospitalYuhua Branch of Nanjing First Hospital,Jiangsu Province,Nanjing210039,China;Department of Orthopaedics,the Fifth Clinical College of Anhui Medical Universitythe Air Force Hospital of the Eastern Theater Command,Jiangsu Province,Nanjing210002,China)

机构地区：[1]南京医科大学附属南京医院南京市第一医院核医学科,江苏南京210019 [2]南京市雨花医院南京市第一医院雨花分院检验科,江苏南京210039 [3]安徽医科大学第五临床学院东部战区空军医院骨科,江苏南京210002

出　　处：《中国医药导报》2023年第20期52-55,共4页China Medical Herald

基　　金：国家自然科学基金资助项目(81600694);中央军委后勤科研项目(CKJ18J019、CKJ20J024、CKJ21J033)。

摘　　要：由成骨细胞和破骨细胞分泌的传统骨转换标志物在骨质疏松症诊疗中发挥重要作用,但骨转换标志物在预测骨质疏松症及脆性骨折的应用上仍需深入研究。作为骨组织中含量最多的细胞,骨细胞在骨转换的调控中扮演重要角色。近来研究表明,由骨细胞分泌的骨转换标志物,如骨硬化蛋白、DKK1和成纤维细胞生长因子23有望成为骨质疏松症及脆性骨折预测的新型骨转换标志物。本文将对上述具有临床应用前景的骨细胞相关标志物在骨质疏松症和脆性骨折预测中的研究新进展进行简要概述,以期为骨质疏松症和脆性骨折的诊断和评估提供理论依据。The traditional bone turnover markers derived from osteoblasts and osteoclasts are useful in the diagnosis and treatment of osteoporosis.However,the usefulness of bone turnover markers in predicting osteoporosis and fragility fractures remains elusive.As the most abundant cell in bone tissue,osteocytes play a central role in regulating bone turnover.Recent research shows that bone turnover markers secreted by osteocytes,such as sclerostin,DKK1,and fibroblast growth factor 23 could be a new type of bone turnover markers for osteoporosis and fragility fracture prediction.This paper will briefly summarize the new research progress of the osteocyte related biomarkers with clinical application prospects in the prediction of osteoporosis and fragility fracture,in order to provide theoretical basis for the diagnosis and evaluation of osteoporosis and fragility fractures.

关 键 词：骨细胞 骨转换标志物 骨质疏松症 骨折 

分 类 号：R683[医药卫生—骨科学]