2型糖尿病并发糖尿病足患者Wanger分级与红细胞压积、白蛋白、红细胞压积和白蛋白差值的相关性  

Correlation of Wanger grade with hematocrit,albumin,difference of hematocrit and albumin in patients with type 2 diabetes mellitus complicated with diabetic foot

作　　者：尚俊良 王广宇[1] 石春红 徐旭英[1] SHANG Junliang;WANG Guangyu;SHI Chunhong;XU Xuying(Department of Sore and Ulcer Vascular Surgery,Beijing Hospital of Traditional Chinese Medicine,Capital Medical University,Beijing 100010,China)

机构地区：[1]首都医科大学附属北京中医医院疮疡血管外科,北京100010

出　　处：《中国医药导报》2023年第21期72-75,共4页China Medical Herald

基　　金：国家自然科学基金面上项目(82174388)。

摘　　要：目的探讨2型糖尿病并发糖尿病足患者Wanger分级与红细胞压积(HCT)、白蛋白(ALB)、HCT和ALB差值(|HCT-ALB|)的相关性。方法回顾性分析2019年1月至2020年1月首都医科大学附属北京中医医院收治的90例2型糖尿病并发糖尿病足患者,按Wanger分级将其分为Wagner1级组30例,Wagner 2~3级组25例,Wagner 4~5级组35例,比较三组临床资料,分析血清HCT、ALB、|HCT-ALB|水平与Wanger分级的相关性。结果Wagner 2~3级组、Wagner 4~5级组年龄、糖尿病病程高于Wagner 1级组,差异有统计学意义(P<0.05)。Wagner 4~5级组钠、血红蛋白、HCT、ALB水平均低于Wagner 1级组、Wagner 2~3级组,白细胞计数、C反应蛋白水平高于Wagner 1级组、Wagner 2~3级组,差异有统计学意义(P<0.05)。Wagner 2~3级组C反应蛋白水平高于Wagner 1级组,HCT、ALB低于Wagner 1级组,差异有统计学意义(P<0.05)。2型糖尿病并发糖尿病足患者Wagner分级与血清HCT、ALB水平均呈负相关(rs<0,P<0.05),与|HCT-ALB|无相关性(P>0.05)。结论血清HCT、ALB水平与2型糖尿病并发糖尿病足患者Wagner分级密切相关,一定程度上可为该病的病情严重程度评估提供参考依据。Objective To investigate the correlation of Wanger grade with hematocrit(HCT),albumin(ALB),difference of HCT and ALB(|HCT-ALB|)in patients with type 2 diabetes mellitus complicated with diabetic foot.Methods A retrospective analysis was performed on 90 patients with type 2 diabetes mellitus complicated with diabetic foot admitted to Beijing Hospital of Traditional Chinese Medicine,Capital Medical University from January 2019 to January 2020,and they were divided into Wagner 1 group(30 cases),Wagner 2-3 group(25 cases),and Wagner 4-5 group(35 cases)according to Wanger grade.Clinical data of the three groups were compared.The correlation between serum levels of HCT,ALB,|HCT-ALB|,and Wanger grade were analyzed.Results The age and duration of type 2 diabetes mellitus in Wagner 2-3 and Wagner 4-5 groups were higher than those in Wagner 1 group,and the differences were statistically significant(P<0.05).The levels of sodium,hemoglobin,HCT,and ALB in Wagner 4-5 group were lower than those in Wagner1 and Wagner 2-3 groups,and the levels of white blood cell count and C-reactive protein were higher than those in Wagner1 and Wagner 2-3 groups,and the differences were statistically significant(P<0.05).The level of C-reactive protein in Wagner 2-3 group was higher than that in Wagner 1 group,and HCT and ALB were lower than those in Wagner 1 group,the differences were statistically significant(P<0.05).Wagner grade of type 2 diabetes mellitus complicated with diabetic foot was negatively correlated with serum HCT and ALB levels(rs<0,P<0.05),but not with|HCT-ALB|(P>0.05).Conclusion Serum HCT and ALB levels are closely related to Wagner grade of patients with type 2 diabetes mellitus complicated with diabetic foot,which can provide a reference for evaluating the severity of the disease to a certain extent.

关 键 词：2型糖尿病 糖尿病足 血清红细胞压积 血清白蛋白 红细胞压积和白蛋白差值 Wanger分级 相关性 

分 类 号：R587.2[医药卫生—内分泌]