应用孟德尔随机化探讨骨密度与腰椎间盘突出症的因果关系  

Causality between osteoporosis and lumbar disc herniation:a Mendelian randomized study

作　　者：许京伟 吴亚东[2] 王静 邓文杰 尹世昌[1] XU Jingwei;WU Yadong;WANG Jing;DENG Wenjie;YIN Shichang(Department of Orthopedics Trauma,Rizhao Hospital of Traditional Chinese Medicine,Shandong Province,Rizhao 276800,China;Department of Spinal Orthopedics,Rizhao Hospital of Traditional Chinese Medicine,Shandong Province,Rizhao 276800,China;Department of Encephalopathy,Rizhao Hospital of Traditional Chinese Medicine,Shandong Province,Rizhao 276800,China;Department of Microorthopedics,Rizhao Hospital of Traditional Chinese Medicine,Shandong Province,Rizhao 276800,China)

机构地区：[1]山东省日照市中医医院创伤骨科,山东日照276800 [2]山东省日照市中医医院脊柱骨科,山东日照276800 [3]山东省日照市中医医院脑病科,山东日照276800 [4]山东省日照市中医医院显微骨科,山东日照276800

出　　处：《中国医药导报》2023年第21期92-96,共5页China Medical Herald

基　　金：山东省自然科学基金创新发展联合基金项目(ZR2021LZY006);山东省中医药科技项目(M-2022092)。

摘　　要：目的通过孟德尔随机化分析方法,研究骨质疏松症(OP)与腰椎间盘突出症(LDH)的因果关系。方法通过全基因组关联分析获得跟骨骨密度的全基因组元分析样本,总结统计约17166350个单核苷酸多态性(SNP),筛选出与OP高度相关的SNP与LDH结局SNP映射,获得工具变量SNP,采用孟德尔随机化方法分析OP与LDH的因果关系。结果共纳入rs10022648、rs10066763、rs10130587等203个SNP为工具变量,MR-Egger回归结果P=0.442324286,不存在水平多效性,IVW分析显示P<0.05,OR=0.893174092(OR_lci95,0.82329084;OR_uci95,0.968989231),骨密度每降低1个标准差,LDH发病风险增加0.89倍,两者之间呈负相关。异质性检验结果为P=0.44,没有异质性。结论以骨密度为代表的OP与LDH之间存在因果关系。Objective To study the causal relationship between osteoporosis(OP)and lumbar disc herniation(LDH)by Mendelian randomization analysis.Methods A genome-wide meta-analysis sample of calcaneal bone density was obtained through genome-wide association analysis,and a total of 17166350 single nucleotide polmorphism(SNPs)were collected.SNP mapping between OP and LDH outcomes was screened out,and instrumental variables SNP was obtained.The causal relationship between OP and LDH were analyzed by Mendelian randomization.Results A total of 203 SNPs,including rs10022648,rs10066763,rs10130587,as included as instrumental variables.The MR-Egger regression result P=0.442324286,indicating no horizontal pleiotropy.IVW analysis showed that P<0.05,OR=0.893174092(OR_lci95,0.82329084;OR_uci95,0.968989231),the risk of LDH increased by 0.89 times for every one SD decrease in BMD,and the two were negatively correlated.The result of heterogeneity test was P=0.44 with no heterogeneity.Conclusion There is a causal relationship between OP represented by bone density and LDH.

关 键 词：骨质疏松症 腰椎间盘突出症 骨密度 孟德尔随机化 

分 类 号：R285.6[医药卫生—中药学]