五味消毒饮加减治疗热毒内陷证重症感染临床疗效及对患者炎症反应、免疫功能的影响  

Clinical Effect of Modified Wuwei Xiaodu Decoction for Severe Infection with InwardInvasion of Heat Toxin Syndrome and Its Effect on Inflammatory Responses andImmune Function

作　　者：施玥 SHI Yue

机构地区：[1]杭州市西溪医院感染科,浙江杭州310023

出　　处：《新中医》2023年第11期67-71,共5页New Chinese Medicine

摘　　要：目的:观察五味消毒饮加减治疗热毒内陷证重症感染的疗效及对患者炎症反应、免疫功能的影响。方法:选取120例热毒内陷证重症感染患者,按随机数字表法分为对照组和观察组各60例。对照组采用对症治疗和常规抗感染治疗,观察组在对照组基础上加用五味消毒饮加减治疗,疗程均为2周。观察并比较2组治疗前后急性生理学及慢性健康状况(APACHEⅡ)评分,序贯器官衰竭(SOFA)评分,CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)、C-反应蛋白(CRP)、降钙素原(PCT)及白细胞计数(WBC)水平。结果:治疗前,2组APACHEⅡ、SOFA评分比较,差异无统计学意义(P>0.05);治疗后,2组APACHEⅡ、SOFA评分均降低(P<0.05),且观察组低于对照组(P<0.05)。治疗前,2组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平比较,差异无统计学意义(P>0.05);治疗后,2组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平均升高(P<0.05),且观察组高于对照组(P<0.05)。治疗前,2组CRP、PCT、WBC水平比较,差异无统计学意义(P>0.05);治疗后,2组CRP、PCT、WBC水平均降低(P<0.05),且观察组低于对照组(P<0.05)。结论:五味消毒饮加减联合对症治疗和常规抗感染治疗能够显著改善热毒内陷证重症感染患者的免疫功能,有效缓解炎症反应,提高抗感染疗效。Objective:To observe the curative effect of modified Wuwei Xiaodu Decoction for severe infection with inward invasion of heat toxin syndrome and its effect on inflammatory responses and immune function.Methods:A total of 120 cases of patients with severe infection with inward invasion of heat toxin syndrome were selected and divided into the control group and the observation group according to the random number table method,with 60 cases in each group.The control group was treated with symptomatic treatment and routine anti-infective therapy,and the observation group was additionally treated with modified Wuwei Xiaodu Decoction based on the treatment of the control group.Both groups were treated for two weeks.Before and after treatment,the scores of Acute Physiology and Chronic Health Evaluation Ⅱ (APACHE Ⅱ) and Sequential Organ Failure Assessment (SOFA), and the levels ofCD3 + , CD4 + and CD4 +/CD8 + , C- reactive protein (CRP), procalcitonin (PCT) and white blood cell (WBC)count in the two groups were observed and compared. Results: Before treatment, there was nosignificant difference being found in the comparison of scores of APACHE Ⅱ and SOFA between the twogroups (P>0.05). After treatment,the scores of APACHE Ⅱ and SOFA in the two groups were decreased(P<0.05), and the scores in the observation group were lower than those in the control group (P<0.05).Before treatment, there was no significant difference being found in the comparison of levels of CD3 + ,CD4 + and CD4 +/CD8 + between the two groups (P>0.05). After treatment,the levels of CD3 +,CD4 + andCD4^(+)/CD8^(+) in the two groups were increased (P<0.05),and the levels in the observation group were higherthan those in the control group (P<0.05). Before treatment,there was no significant difference being foundin the comparison of levels of CRP, PCT and WBC between the two groups (P>0.05). After treatment,levels of CRP, PCT and WBC in the two groups were decreased (P<0.05), and the levels in theobservation group were lower than those in the control

关 键 词：重症感染 五味消毒饮加减 热毒内陷证 免疫功能 炎症反应 

分 类 号：R459.7[医药卫生—急诊医学]