苏黄止咳胶囊对慢性阻塞性肺疾病稳定期患者肺功能及气道重塑的影响  

Effects of Suhuang Zhike Capsules on Lung Function and Airway Remodeling in Patients in Stable Stage of Chronic Obstructive Pulmonary Disease

作　　者：张丹珍 洪小兵[1] 贺洁 ZHANG Danzhen;HONG Xiaobing;HE Jie

机构地区：[1]台州市中医院呼吸与危重症医学科,浙江台州318000

出　　处：《新中医》2023年第11期86-89,共4页New Chinese Medicine

摘　　要：目的:观察苏黄止咳胶囊对慢性阻塞性肺疾病稳定期患者肺功能及气道重塑的影响。方法:选择82例慢性阻塞性肺疾病稳定期患者为研究对象,按随机数字表法随机分为治疗组和对照组各41例。对照组行常规对症治疗,治疗组在对照组基础上服用苏黄止咳胶囊治疗,共治疗3个月。比较2组治疗前后的肺功能情况、气道重塑情况、炎症水平以及改良英国mMRC呼吸困难指数评分量表(mMRC)评分。结果:治疗前,2组第1秒用力呼气容积(FEV1)、第1秒用力呼气容积占用力肺活量的百分比(FEV1/FVC)比较,差异无统计学意义(P>0.05);治疗后,2组FEV1、FEV1/FVC均升高(P<0.05),且治疗组高于对照组(P<0.05)。治疗前,2组气道壁面积(WA)、气道壁厚度(T)比较,差异无统计学意义(P>0.05);治疗后,2组WA、T均降低(P<0.05),且治疗组低于对照组(P<0.05)。治疗前,2组血清白细胞介素-6(IL-6)、白细胞介素-8(IL-8)水平比较,差异无统计学意义(P>0.05);治疗后,2组血清IL-6、IL-8水平均降低(P<0.05),且治疗组低于对照组(P<0.05)。治疗前,2组mMRC评分比较,差异无统计学意义(P>0.05);治疗后,2组mMRC评分均降低(P<0.05),且治疗组低于对照组(P<0.05)。结论:苏黄止咳胶囊治疗慢性阻塞性肺疾病稳定期患者,可提高肺通气功能并延缓气道重塑的形成和发展。Objective:To observe the effect of Suhuang Zhike Capsules on lung function and airway remodeling in patients in stable stage of chronic obstructive pulmonary disease(COPD).Methods:A total of 82 cases of patients in stable stage of COPD were selected as the study subjects and divided into the treatment group and the control group according to the random number table method,with 41 cases in each group.The control group was treated with conventional symptomatic treatments,and the treatment group was additionally treated with Suhuang Zhike Capsules based on the treatment of the control group.Both groups were treated for three months.The lung function,airway remodeling,inflammation levels,and the scores of modified Medical Research Council(mMRC)dyspnea scale were compared between the two groups before and after treatment.Results:Before treatment,there was no significant difference being found in the comparison of the forced expiratory volume in one second(FEV1)and the ratio of the forced expiratory volume in the one second to the forced vital capacity of the lungs(FEV1/FVC)between the two groups(P>0.05).After treatment,FEV1 and FEV1/FVC in the two groups were increased(P<0.05),and FEV1 and FEV1/FVC in the treatment group were higher than those in the control group(P<0.05).Before treatment,there was no significant difference being found in the comparison of the wall area(WA)and wall thickness(T)of airway between the two groups(P>0.05).After treatment,WA and T in the two groups were decreased(P<0.05),and WA and T in the treatment group were lower than those in the control group(P<0.05).Before treatment,there was no significant difference being found in the comparison of the levels of interleukin-6(IL-6)and interleukin-8(IL-8)in serum between the two groups(P>0.05).After treatment,the levels of IL-6 and IL-8 in serum in the two groups were decreased(P<0.05),and the two levels in the treatment group were lower than those in the control group(P<0.05).Before treatment,there was no significant difference being found in the c

关 键 词：慢性阻塞性肺疾病稳定期 苏黄止咳胶囊 肺功能 气道重塑 

分 类 号：R563[医药卫生—呼吸系统]