血小板裂解物在再生医学和细胞治疗领域的研究进展  

Research progress of platelet lysates in the field of regenerative medicine and cell therapy

作　　者：左佳蕙 李一鸣[1] 杨舒苇 黄力勤 ZUO Jiahui;LI Yiming;YANG Shuwei;HUANG Liqin(Shenzhen Blood Center,Shenzhen 518035,China)

机构地区：[1]深圳市血液中心,广东深圳518035

出　　处：《中国输血杂志》2023年第7期642-646,共5页Chinese Journal of Blood Transfusion

基　　金：深圳市血液中心科研课题(SZBC202316);中国输血协会威高基金项目(CSBT-2020-08)。

摘　　要：血小板裂解物(human platelet lysate,HPL)是1种具有促进组织修复、细胞增殖、炎症控制等多种功能的新型生物材料。我们介绍了血小板裂解物在再生医学和细胞治疗领域的发展,对其应用形式进行了分类概述,并以血小板裂解物促进细胞增殖的潜力为切入点,分析了其作为细胞培养基补充剂的优势所在。鉴于目前尚无血小板裂解物制备的标准程序,我们通过对原材料来源、供体变异性、制备工艺等标准化要素的梳理,以期为未来我国学界建立相关行业标准提供参考。Human platelet lysates(HPL),as a new type of biomaterial,can promote tissue repair,cell proliferation and inflammation control.This paper introduced the development of HPL in the field of regenerative medicine and cell therapy and summarizes their application.The potential of HPL to promote cell proliferation was used as an entry point to show its advantages as a supplement of cell culture medium.Since there is currently no standard procedure for HPL preparation,this paper sorts out the standardization elements such as raw materials source,donor variability and preparation technology,in order to provide reference for the establishment of standards of relevant industry in the future.

关 键 词：血小板裂解物 细胞治疗 再生医学 培养基补充剂 制备标准化 

分 类 号：R331.143[医药卫生—人体生理学] R457.1[医药卫生—基础医学]