血小板保存相关添加剂研究现状  

Research status of additives related to platelet preservation

作　　者：李梦雪 王志成 LI Mengxue;WANG Zhicheng(Huashan Hospital Affiliated to Fudan University,Shanghai 200040,China)

机构地区：[1]复旦大学附属华山医院输血科,上海200040

出　　处：《中国输血杂志》2023年第7期647-650,共4页Chinese Journal of Blood Transfusion

基　　金：上海市自然科学基金(22ZR1409400)。

摘　　要：血小板在止血、炎症、肿瘤转移、伤口愈合及防御反应中起到了重要作用,然而其常规保存需要特定温度且保存时间一般为5~7 d,同时,血小板储存损伤和细菌滋生会影响其保存时间及保存质量。此外,常规输注后会产生非溶血性发热、过敏、循环超负荷及输血相关急性肺损伤等严重不良反应。这些都限制了血小板制品在临床中的应用。但是,与血小板保存相关的添加剂可以降低它们发生的可能性。因此,我们就近年来血小板保存相关添加剂的研究现状,以及改善血小板储存损伤、提高血小板保存特性等方面进行了综述。Platelets play an important role in hemostasis,inflammation,tumor metastasis,wound healing and defense response,but its routine storage requires a specific temperature and the storage time is generally limited to 5~7 d,at the same time,platelet storage damage and bacterial breeding will limit its storage time.In addition,routine transfusion can cause serious adverse reactions such as non-hemolytic fever,allergies,circulatory overload,and transfusion-related acute lung injury.These limit the clinical application of platelet products.However,additives associated with platelet preservation can reduce the likelihood of their occurrence.Therefore,this article reviews the research status of additives related to platelet preservation in recent years,as well as improving platelet storage damage and improving platelet preservation characteristics.

关 键 词：输血 血小板添加剂 血小板保存 血小板保存损伤 

分 类 号：R331.143[医药卫生—人体生理学]