rhsTM对动脉粥样硬化的治疗作用机制研究进展  

Research progress on therapeutic role of recombinant human soluble thrombomodulin in atherosclerosis

作　　者：赵灵芝 何艳君 谢建琴[3] 尤崇革[2] ZHAO Lingzhi;HE Yanjun;XIE Jianqin;YOU Chongge(Second Clinical Medical College of Lanzhou University,Lanzhou 730000,Gansu,China;Laboratory Medicine Center,Lanzhou University Second Hospital,Lanzhou 730000,Gansu,China;Anesthesiology Department,Lanzhou University Second Hospital,Lanzhou 730000,Gansu,China)

机构地区：[1]兰州大学第二临床医学院,甘肃兰州730000 [2]兰州大学第二医院检验医学中心,甘肃兰州730000 [3]兰州大学第二医院麻醉科,甘肃兰州730000

出　　处：《中国临床药理学与治疗学》2023年第7期832-840,共9页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：甘肃省自然科学基金资助项目(21JR7RA407);甘肃省科技厅重点研发计划项目(21YF5FA126);兰州大学第二医院博士研究生培养专项基金项目(YJS-BD-23)。

摘　　要：动脉粥样硬化(atherosclerosis,AS)是一种由脂质堆积引起的多灶性、缓慢进展性、免疫炎症性血管疾病。由AS引发的急性心脑血管疾病是全球最严峻的生命威胁之一。内皮细胞损伤、血管炎症刺激、脂质代谢异常、凝血系统紊乱是AS的主要病理机制。血栓调节蛋白(thrombomodulin,TM)是一种主要表达在血管内皮细胞表面的跨膜糖蛋白。它通过抗凝、抗炎和细胞保护的功能在维持血管系统的动态平衡中发挥重要作用。以TM胞外区域为基本结构的重组人可溶性血栓调节蛋白(recombinant human soluble TM,rhsTM),有很大潜能成为治疗AS的新工具。该文简述了TM的结构与功能,并对rhsTM在AS中的治疗作用机制进行了综述,以期为AS的防治提供新思路。Atherosclerosis is a multifocal,smoldering,immunoinflammatory disease caused by lipid accumulation.Acute cardio-cerebrovascular disease caused by AS is one of the most serious life threats in the world.Endothelial cell injury,vascular inflammatory stimulation,abnormal lipid metabolism and coagulation disorder are the main pathological mechanisms of AS.Thrombomodulin(TM)is a transmembrane glycoprotein mainly expressed on the surface of endothelium.It plays a key role in maintaining the dynamic equilibrium of the vascular system through its functions of anti-coagulation,anti-inflammation and cell protection.Recombinant human soluble thrombomodulin(rhsTM),a soluble form of human TM containing the extracellular domain of TM,might be effective in the treatment of AS.This review summarizes the structure and function of TM and the mechanism of rhsTM in the treatment of AS.Aiming to provide new ideas for the prevention and treatment of AS.

关 键 词：动脉粥样硬化 血栓调节蛋白 炎症 凝血 

分 类 号：R543.5[医药卫生—心血管疾病]