生物钟节律紊乱与高血压  

Biological clock rhythm disorder and hypertension

作　　者：李路明 施海媛 刘如谭 沙一君 何明利 Li Luming;Shi Haiyuan;Liu Ru;Tan Shayijun;He Mingli(Department of Neurology,the Affiliated Hospital of Lianyungang,Xuzhou Medical University(the First People's Hospital of Lianyungang),Lianyungang 222061,China;Lianyungang Clinical Medical College,Nanjing Medical University,Lianyungang 222061,China)

机构地区：[1]徐州医科大学附属连云港医院,连云港市第一人民医院神经内科,连云港222061 [2]南京医科大学连云港临床医学院,连云港222061

出　　处：《国际脑血管病杂志》2023年第4期303-307,共5页International Journal of Cerebrovascular Diseases

基　　金：国家自然科学基金(81970348)。

摘　　要：生物钟蛋白参与许多重要生理过程的调节,包括血压。核心生物钟基因的缺失或突变可造成血压水平升高以及血压节律紊乱,加重血管功能损伤,最终导致缺血性卒中的发生和发展以及转归不良。文章对生物钟节律的分子机制、生物钟基因与血压调控机制之间的联系、昼夜节律紊乱在高血压发生发展中的作用机制以及血压节律紊乱与卒中之间的关系进行了综述。Biological clock proteins are involved in the regulation of many important physiological processes,including blood pressure.The deletion or mutation of core circadian clock genes may cause elevated blood pressure levels and disrupted blood pressure rhythms,exacerbating vascular function damage,and ultimately leading to the occurrence,development and poor outcome of ischemic stroke.This article reviews the molecular mechanism of biological clock rhythm,the relationship between biological clock gene and blood pressure regulation mechanism,the mechanism of circadian rhythm disorder in the occurrence and development of hypertension,and the relationship between blood pressure rhythm disorder and stroke.

关 键 词：生物钟蛋白 高血压 血压 卒中 昼夜节律 周期生物钟蛋白 基因表达调控 

分 类 号：R544.1[医药卫生—心血管疾病]