不同中性粒细胞与淋巴细胞比值组间COVID-19胸部HRCT表现分析  

Analysis of Coronavirus Disease 2019 Chest High-resolution Computed Tomography Manifestations between Groups with Different Neutrophil-to-Lymphocyte Ratios

作　　者：霍萌[1] 李玲 孙莹[1] 张明霞[1] 孙磊[1] 郭佳 杜常月 李兴鹏 郝琪 张妍 段淑红[2] 刘晓燕[2] 刘薇[1] 段永利[1] 张春燕[1] 王仁贵[1] HUO Meng;LI Ling;SUN Ying;ZHANG Mingxia;SUN Lei;GUO Jia;DU Changyue;LI Xingpeng;HAO Qi;ZHANG Yan;DUAN Shuhong;LIU Xiaoyan;LIU Wei;DUAN Yongli;ZHANG Chunyan;WANG Rengui(Department of Radiology,Beijing Shijitan Hospital,Capital Medical University,Beijing 100038,China;Department of Infectious Diseases,Beijing Shijitan Hospital,Capital Medical University,Beijing 100038,China)

机构地区：[1]首都医科大学附属北京世纪坛医院放射科,北京100038 [2]首都医科大学附属北京世纪坛医院感染科,北京100038

出　　处：《CT理论与应用研究（中英文）》2023年第3期387-394,共8页Computerized Tomography Theory and Applications

摘　　要：目的:探讨中性粒细胞与淋巴细胞比(NLR)与COVID-19胸部HRCT表现的相关性。材料与方法:回顾性分析132例于2022年12月1日至2023年2月1日就诊于首都医科大学附属北京世纪坛医院感染科确诊COVID-19患者的NLR与胸部HRCT,以NLR截断值3.0把患者分为两组,分析其HRCT影像特征、影像表现模式。对于正态分布的计量资料组间采用连续变量的t检验;对于非正态分布的数据以中位数、四分位数表示,通过Mann-Whitney U检验进行比较;对于计数资料通过频率表示,并采用卡方检验或Fisher精确检验进行组间比较。结果:低NLR组比高NLR组有更多的≤5个病灶及病灶占比≤10%,高NLR组比低NLR组有更多的病灶数目>10个及病灶占比>50%;高NLR组比低NLR组更易出现混合密度影、铺路石征、马赛克征、反晕征、胸膜下黑带、拱廊征、牵拉支扩;高NLR组比低NLR组更易表现为非特异性间质性肺炎样、机化性肺炎样、弥漫肺泡损伤样改变。结论:不同NLR其COVID-19胸部HRCT表现不同,高NLR组更易出现混合密度影、铺路石征、马赛克征、反晕征、胸膜下黑带、拱廊征、牵拉支扩;影像表现模式更易表现为非特异性间质型肺炎、机化性肺炎、弥漫性肺泡损伤。Objective:This study aimed to investigate the correlation between the neutrophil-to-lymphocyte ratio(NLR)and chest high-resolution computed tomography(HRCT)findings of coronavirus disease 2019(COVID-19).Materials and Methods:NLR and chest HRCT findings of 132 patients diagnosed with COVID-19 in the department of infectious diseases of Beijing Shijitan Hospital Capital Medical University from December 1,2022 to February 1,2023 were retrospectively analyzed.The patients were divided into two groups with NLR cut-off value of 3.0,and their HRCT characteristics and imaging manifestation patterns were analyzed.For the measurement data of normal distribution,the t-test of continuous variables was used between the groups.The data of non-normal distribution are expressed as median and quartile and compared using Mann-Whitney U test.The counting data are expressed as frequency,and the chi-squared or Fisher's exact test was used for comparison between the groups.P<0.05 indicates that the difference is statistically significant.Results:The number of lesions≤5 and the proportion of lesions≤10%were higher in the low NLR group than that in the high NLR group.The number of lesions>10 and the proportion of lesions>50%were higher in the high NLR group than that in the low NLR group.The high NLR group was prone to mixed density shadow,crazy-paving pattern,mosaic sign,anti-halo sign,subpleural black belt,arcade-like sign than that in the low NLR group.The high NLR group was most likely to have nonspecific interstitial pneumonia-like,organizing pneumonia-like,and diffuse alveolar damage-like patterns than that in the low NLR group.Conclusion:Different NLRs have different manifestations of COVID-19 chest HRCT.The high NLR group is more prone to mixed density shadow,crazy-paving pattern,mosaic sign,anti-halo sign,subpleural black belt,and arcade-like sign,as well as most likely to have radiologic patterns of nonspecific interstitial pneumonia,organizing pneumonia,diffuse alveolar damage.

关 键 词：胸部HRCT COVID-19 中性粒细胞与淋巴细胞比 

分 类 号：R814[医药卫生—影像医学与核医学]