新型冠状病毒感染患者一年随访骨密度及体质成分特征分析  

Bone Mineral Density and Body Composition Characteristics of Patients with Coronavirus Disease 2019 after One-year Follow-up

作　　者：管文敏 魏璇 孙婧 魏巍[2] 张婷婷[1] 颜颖 宋丽君 千虎胜 王大宁 刘广红[5] 乔美琴 任露[7] 杨正汉[1] 徐岩[1] 王振常[1] GUAN Wenmin;WEI Xuan;SUN Jing;WEI Wei;ZHANG Tingting;YAN Ying;SONG Lijun;QIAN Husheng;WANG Daning;LIU Guanghong;QIAO Meiqin;REN Lu;YANG Zhenghan;XU Yan;WANG Zhenchang(Department of Radiology,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China;Science and Technology Department,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China;Department of Radiology,Yanbian Korean Medical Hospital,Yanji 133000,China;Image Center,Baicheng Municipal Hospital,Baicheng 137000,China;Department of Radiology,The Third Affiliated Hospital of Luohe Medical College,Luohe 462000,China;Medical Imaging Department,Ordos Central Hospital,Ordos 017000,China;Department of Radiology,Changsha Central Hospital,Changsha 410004,China)

机构地区：[1]首都医科大学附属北京友谊医院放射科,北京100050 [2]首都医科大学附属北京友谊医院科技处,北京100050 [3]延边朝医医院放射科,吉林延吉133000 [4]白城市医院影像中心,吉林白城137000 [5]漯河医学高等专科学校第三附属医院放射科,河南漯河462000 [6]鄂尔多斯市中心医院医学影像科,内蒙古鄂尔多斯017000 [7]长沙市中心医院放射科,长沙410004

出　　处：《CT理论与应用研究（中英文）》2023年第3期411-418,共8页Computerized Tomography Theory and Applications

基　　金：国家自然科学基金(基于胸部CT数据采用最优传输方法的新冠肺炎住院时长预测模型(62141110));北京市自然科学基金(基于暗场计算机断层扫描技术的肺局灶性磨玻璃阴影的检出及分类研究(7232033));首都医科大学附属北京友谊医院“友谊种子计划”人才项目(肥胖症伴2型糖尿病患者减重代谢术后骨损伤机制研究(YYZZ202130))。

摘　　要：COVID-19虽以肺部表现为主,但该病除累及呼吸系统外,还可累及多个系统,其中尤以对骨肌系统影响的研究较为缺乏。本研究纳入33例有入院、出院及1年后随访胸部CT资料的COVID-19患者,分析其骨及体质成分特征,共纳入无症状感染者、轻型、普通型、重型患者各2、8、19和4人,无危重型患者。平均住院时长为(29.5±9.6)d,平均随访时间为(423.0±53.6)d。入院、出院及1年后胸椎骨密度未见明显变化;胸12~腰1椎间隙层面腹部皮下脂肪、腹腔内脂肪及腹部总脂肪面积亦未见明显变化。无症状感染者及轻型组患者入院及1年随访胸1~胸12平均BMD高于普通型及重型组;普通型及重型组患者入院及1年后随访腹腔内脂肪面积及腹部总脂肪面积大于无症状感染者及轻型组。本研究首次探索COVID-19对骨肌系统的影响,提示感染COVID-19一年后,并未导致患者胸椎骨密度和腹部脂肪发生明显变化。Although coronavirus disease 2019(COVID-19)primarily affects the respiratory system,this disease can affect multiple systems,including the musculoskeletal system.However,studies regarding the effect of COVID-19 on musculoskeletal system are limited.This study analyzed the bone mineral density(BMD)and body composition of 33 patients with COVID-19 using their chest CT scans at admission,discharge,and one-year follow-up.Among the patients,2 were asymptomatic,8 had mild symptoms,19 had ordinary symptoms,and 4 had severe symptoms,and no critical patients were included.The mean length of hospital stay was(29.5±9.6)days,and the mean duration to follow-up was(423.0±53.6)days.The study found no significant changes in BMD of segmental or total thoracic vertebrae at admission,discharge,and one-year follow-up.No significant changes were observed in the subcutaneous adipose tissue(SAT)area,visceral adipose tissue(VAT)area,and total adipose tissue(TAT)of the mid-slice of the T12~L1 intervertebral disc.However,the asymptomatic and mild group had a higher average BMD of the T1~T12 than that of the common and severe group at admission and one-year followup.The common and severe group had higher VAT and TAT area than those of the asymptomatic and mild group at admission and one-year follow-up.This study provides valuable insights into the effects of COVID-19 on the musculoskeletal system and suggests that COVID-19 does not significantly affect thoracic BMD and abdominal adipose tissue after one year of infection.

关 键 词：定量CT 多模态影像 新型冠状病毒感染 骨密度 体质成分 

分 类 号：R814[医药卫生—影像医学与核医学]