Effects of dietary supplementation of bacteriophage cocktail on health status of weanling pigs in a non-sanitary environment  

作　　者：YoHan Choi Abdolreza Hosseindoust Sang Hun Ha Joeun Kim YeJin Min YongDae Jeong JunYoung Mun SooJin Sa JinSoo Kim 

机构地区：[1]Swine Science Division,National Institute of Animal Science,Rural Development Administration,Cheonan 31000,Republic of Korea [2]Department of Animal Industry Convergence,Kangwon National University,Chuncheon 24341,Republic of Korea

出　　处：《Journal of Animal Science and Biotechnology》2023年第4期1661-1677,共17页畜牧与生物技术杂志（英文版）

基　　金：the support of“Cooperative Research Program for Agriculture Science and Technology Development(Project No.PJ01694303)”Rural Development Administration,Korea。

摘　　要：Background The study evaluated the effects of bacteriophage cocktail(BP)and ZnO administered during weaning time for piglets exposed to a non-sanitary environment.The bacteriophages were designed to eliminate Escherichia coli(K88,K99 and F41),Salmonella(typhimurium and enteritidis),and Clostridium perfreingens(types A and C).Forty 21-day-old crossbreed piglets were assigned to four treatments,including the PC(sanitary environment),NC(nonsanitary environment),BP(NC plus 108 pfu/kg BP),and ZO(NC plus 2,500 mg/kg ZnO).Piglets in the NC,BP and ZO were kept in a non-sanitary environment for 14 d,which was contaminated with the feces of infected pigs.Results Pigs in the BP and ZO treatments had a higher final body weight compared with the NC.The NC treatment showed the highest concentration of inflammatory cytokines including interleukin(IL)-1β,IL-6 and tumor necrosis factor-αin the plasma.The administration of BP and ZO showed lower myeloperoxidase concentrations compared with the NC.The NC treatment showed a lower concentration of superoxide dismutase in serum compared with the PC.Among the treatments in non-sanitary environment,the NC treatment showed a higher concentration of malondialdehyde compared with the ZO.The PC treatment showed a lower concentration of butyric acid in the feces compared with the BP treatment.Among non-sanitary treatments,the villus height in the duodenum was greater in the BP and ZO compared with the NC.The lower abundance of Proteobacteria phylum was observed in the BP and PC treatments compared with the NC.The highest relative abundance of Eubacterium was recorded in the BP treatment.The abundance of Megasphaera and Schwartzia was higher in the NC pigs compared with the BP piglets.The abundance of Desulfovibrio was lower in the supplemented treatments(BP and ZO)compared with non-supplemented(NC and PC).The abundance of Cellulosilyticum genera was higher in the BP and ZO treatments rather than in the NC.The piglets in the NC treatment had the highest abundance of Escherichia-Shigella,fol

关 键 词：Antioxidant Cytokines DIARRHEA Fecal score Inflammation Microbiota PROTEOBACTERIA 

分 类 号：S828.5[农业科学—畜牧学]