抗磷脂综合征对女性不孕及体外受精-胚胎移植助孕结局的研究进展  

Advances in the Effects of Antiphospholipid Syndrome on Female Infertility and Outcomes of Assisted Reproductive Technologies

作　　者：郎曼凝 李维宏[1] LANG Man-ning;LI Wei-hong(Reproductive Medical Center,The First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China)

机构地区：[1]重庆医科大学附属第一医院生殖医学中心,重庆400016

出　　处：《中山大学学报（医学科学版）》2023年第4期582-586,共5页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：国家自然科学基金(81501335);重庆市自然科学基金(CSTB2022NSCQ-MSX0086)。

摘　　要：抗磷脂综合征(APS)是一种与抗磷脂抗体持续存在有关的自身免疫性疾病,其主要特征为血栓形成和妊娠相关疾病的发生。APS可能通过影响卵巢功能、子宫蜕膜化等方式对女性的生殖功能造成不利的影响,并可能在体外受精-胚胎移植(IVF-ET)治疗中引起胚胎种植失败、胚胎种植后的妊娠丢失。常规在不孕人群IVF-ET前进行APS的筛查、治疗尚存在争议,应对患者的风险进行个体化评估,采取相应的管理措施,提高患者的助孕成功率,降低妊娠期母胎风险。本文综述了APS对不孕及IVF助孕结局的影响与人群的管理,为临床诊治提供新思路。Antiphospholipid syndrome(APS)is an autoimmune disease characterized by the persistent presence of antiphospholipid antibodies,which are associated with thrombosis and pregnancy-related complications.APS may have ad⁃verse effects on female reproductive function by affecting ovarian function,endometrialization,and other mechanisms,and may lead to embryo implantation failure and pregnancy loss during in vitro fertilization and embryo transfer(IVF-ET)treatments.The routine screening and management of APS before IVF-ET in infertile populations remains controversial and requires individualized risk assessment and appropriate management measures to improve the success rate of assisted reproductive technologies(ART)and reduce maternal and fetal risks during pregnancy.This review summarizes the effects of APS on female infertility and outcomes of ART,as well as the management of the population affected by APS,providing new insights for clinical diagnosis and treatment.

关 键 词：抗磷脂综合征 不孕 体外受精-胚胎移植 

分 类 号：R71[医药卫生—妇产科学]