妊娠期糖尿病和健康孕妇体内血清维生素D含量及糖化血红蛋白水平的差异性、相关性研究  

Differences and Correlations of Serum Vitamin D Levels and Glycated Hemoglobin Levels in Gestational Diabetes and Healthy Pregnant Women

作　　者：余玲 罗娟 YU Ling;LUO Juan(Department of Obstetrics and Gynecology,Huanggang Maternal and Child Health Hospital,Huanggang,Hubei Province,438000 China;Department of Obstetrics and Gynecology,Huanggang Central Hospital,Huanggang,Hubei Province,438000 China)

机构地区：[1]黄冈市妇幼保健院产科,湖北黄冈438000 [2]湖北省黄冈市中心医院妇产科,湖北黄冈438000

出　　处：《糖尿病新世界》2023年第12期37-40,共4页Diabetes New World Magazine

摘　　要：目的研究分析妊娠糖尿病与健康孕妇体内血清维生素D含量、糖化血红蛋白水平(HbA1c)的差异性及相关性。方法择取2022年1—12月在黄冈市妇幼保健院产科进行产前检查的90例妊娠期糖尿病孕妇,纳入观察组;选取同时间段内的90名健康孕妇,纳入对照组,对两组血清维生素D、HbA1c指标水平进行检测,研究分析妊娠期糖尿病产妇血清维生素D含量及HbA1c指标水平的差异性、相关性。结果观察组血清HbA1c水平高于对照组,血浆维生素D水平低于对照组,差异有统计学意义(P<0.05)。HbA1c正常组血浆25-OH-D水平高于高HbA1c组,差异有统计学意义(P<0.05)。HbA1c指标水平和维生素D含量呈负相关(P<0.05)。结论与健康孕妇相比,妊娠期糖尿病孕妇血清维生素D含量更低,且维生素D含量和HbA1c指标水平之间关系为负相关,对维生素D含量进行检测,能够为孕妇是否出现妊娠糖尿病提供诊断依据。Objective To study and analyze the difference and correlation between serum vitamin D level and glycosylated hemoglobin Alc(HbA1c)in gestational diabetes and healthy pregnant women.Methods 90 pregnant women with gestational diabetes who underwent prenatal examination in Huanggang Maternal and Child Health Hospital from January to December 2022 were selected and included in the observation group;90 healthy pregnant women in the same period were selected and included in the control group.The levels of serum vitamin D and HbA1c in the two groups were detected.The differences and correlations between the levels of serum vitamin D and HbA1c in pregnant women with diabetes were analyzed.Results The serum HbA1c level in the observation group was higher than that in the control group,while the plasma vitamin D level was lower than that in the control group,and the difference was statistically significant(P<0.05).The plasma 25-OH-D levels in the HbA1c normal group were lower than those in the high HbA1c group,and the difference was statistically significant(P<0.05).The HbA1c indicator level was negatively correlated with vitamin D content(P<0.05).Conclusion Compared with healthy pregnant women,pregnant women with gestational diabetes have lower serum vitamin D levels,and the relationship between vitamin D levels and HbA1c index levels is negatively correlated.The test of vitamin D level can provide a diagnostic basis for the development of gestational diabetes in pregnant women.

关 键 词：妊娠期糖尿病 血清维生素D含量 糖化血红蛋白水平 差异性 相关性 

分 类 号：R587[医药卫生—内分泌]