Antifertility effects of levonorgestrel,quinestrol,and their mixture(EP-1)on plateau zokor in the Qinghai–Tibetan Plateau  

作　　者：Yukun KANG Yuchen TAN Chan WANG Baohui YAO Kang AN Ming LIU Junhu SU 

机构地区：[1]College of Grassland Science,Key Laboratory of Grassland Ecosystem(Ministry of Education),Gansu Agricultural University,Lanzhou,China [2]Gansu Agricultural University-Massey University Research Centre for Grassland Biodiversity,Gansu Agricultural University,Lanzhou,China [3]International Society of Zoological Sciences,Beijing,China

出　　处：《Integrative Zoology》2022年第6期1002-1016,共15页整合动物学（英文版）

基　　金：supported by the Program for Longyuan Youth Innovation Talents of Gansu Province of China(LQ20180918-2);the Technology Support Program of Gansu Forestry and Grassland Administration(LCJ20210020);the International Partnership Program of Chinese Academy of Sciences(152111KYSB20160089).

摘　　要：The plateau zokor(Eospalax baileyi)is a key species in the Qinghai-Tibetan Plateau ecosystem,and fertility control could be an ideal approach to manage populations of this subterranean species.In this laboratory study,we explored the effects of the mixture of levonorgestrel and quinestrol(EP-1,1:2),quinestrol(E),and levonorgestrel(P)on the reproductive status of plateau zokors.Groups of 5 animals of each sex were treated with different concentrations of EP-1(1,5,and 10 mg/kg),E(0.33,3.3,and 6.6 mg/kg),and P(0.67,3.35,and 6.7 mg/kg)by oral gavage over 7 successive days and killed on day 15.Body mass reduction was observed in the EP-1 and E groups.EP-1 and E significantly reduced the weight of testis and epididymis at 10 and 3.3 mg/kg,respectively.Sperm count and motility were significantly reduced by 5 mg/kg EP-1 and 0.33 mg/kg E.The levels of serum testosterone,estradiol,luteinizing hormone,and follicle stimulating hormone were significantly reduced by 5 mg/kg EP-1 and 3.3 mg/kg E.EP-1 and E significantly increased the uterine and ovarian weights at 10 and 3.3 mg/kg,respectively.In the plateau zokors,treatment with P had no influence on the reproductive status.These data demonstrate that EP-1 and E have an inhibitory effect on a range of reproductive parameters in the plateau zokors.Further assessment is required to determine the effects on breeding and recruitment in enclosure orfield experiments.

关 键 词：EP-1 fertility inhibition LEVONORGESTREL QUINESTROL subterranean rodent 

分 类 号：S44[农业科学—农业昆虫与害虫防治]