Anti-fertility effect of levonorgestrel and/or quinestrol on striped field mouse(Apodemus agrarius):evidence from both laboratory and field experiments  

作　　者：Xiaoning CHEN Xiang HOU Tuo FENG Ning HAN Jing WANG Gang CHANG 

机构地区：[1]Shaanxi Key Laboratory for Animal Conservation,Shaanxi Institute of Zoology,Xi’an,China [2]College of Life Sciences,Shaanxi Normal University,Xi’an,China

出　　处：《Integrative Zoology》2022年第6期1041-1052,共12页整合动物学（英文版）

基　　金：supported by the Science and Technology Program of Shaanxi Academy of Sciences(2017K-11,2018k-04,2020k-21);the international Partnership of Chinese Academy of Sciences(Grant No.152111KYSB20160089);the Key Research and Development Program of Shaanxi(2018NY-135,2021NY-042);the Science and Technology Innovation Program of Shaanxi Academy of Forestry(SXLK2020-0209);the Second Tibetan Plateau Scientific Expedition and Research Program(STEP,2019QZKK0501).

摘　　要：The effect of combined levonorgestrel(P)and quinestrol(E)on the fertility of stripedfield mouse(Apodemus agrarius)has not been evaluated.We performed a series of experiments in both the laboratory andfield to assess the effect of P and/or E on the fertility of A.agrarius.In the laboratory,to test the time-dependent anti-fertility ef-fects of P and E,as well as their mixtures,90 male stripedfield mice were randomly assigned to 6 treatment groups(n=60),and a control group(n=30).Mice in 3 treatment groups were administered 1 of the 3 compounds(1 mg�kg–1[body weight]EP-1,0.34 mg�kg–1 E,0.66 mg�kg–1 P)for 3 successive days(another half for 7 suc-cessive days)via oral gavage;mice were then sacrificed 15 and 45 days after initiating the gavage treatment.Ourfindings indicated that E and EP-1 treatment,but not P or control treatment,significantly decreased the sperm count in the caudal epididymis,as well as the weight of the testes,epididymides,and seminal vesicles.Additionally,fer-tile female mice mated with E-and EP-1-treated males produced smaller pups.These data indicate that E and EP-1 can induce infertility in male A.agrarius.In thefield,the population density of A.agrarius was significantly influ-enced by EP-1,and the rodent density in the treatment group was lower than that in the control group.Overall,our results indicate that EP-1 is an effective contraceptive in A.agrarius,a dominant rodent species in the farmland.

关 键 词：Apodemus agrarius fertility control LEVONORGESTREL QUINESTROL 

分 类 号：S44[农业科学—农业昆虫与害虫防治]