Deafening-induced rapid changes to spine synaptic connectivity in the adult avian vocal basal ganglia  

作　　者：Xiaojuan ZHOU Yalan CHEN Jikan PENG Mingxue ZUO Yingyu SUN 

机构地区：[1]Beijing Key Laboratory of Gene Resource and Molecular Development,College of Life Sciences,Bejiing Normal University,Beijing,China [2]Chinese Institute for Brain Research(CIBR),Beijing,China [3]Technology Center for Protein Sciences,Tsinghua University,Beijing,China [4]School of Life Sciences,Westlake University,Hangzhou,China

出　　处：《Integrative Zoology》2022年第6期1136-1146,共11页整合动物学（英文版）

基　　金：supported by the National Natural Science Foundation of China(31472001,31272310).

摘　　要：The basal ganglia have been implicated in auditory-dependent vocal learning and plasticity in human and songbirds,but the underlying neural phenotype remains to be clarified.Here,using confocal imaging and three-dimensional electron microscopy,we investigated striatal structural plasticity in response to hearing loss in Area X,the avian vocal basal ganglia,in adult male zebrafinch(Taeniopygia guttata).We observed a rapid elongation of dendritic spines,by approximately 13%,by day 3 after deafening,and a considerable increase in spine synapse density,by approximately 61%,by day 14 after deafening,compared with the controls with an intact cochlea.Thesefind-ings reveal structural sensitivity of Area X to auditory deprivation and suggest that this striatal plasticity might contribute to deafening-induced changes to learned vocal behavior.

关 键 词：basal ganglia dendritic spine SONGBIRD SYNAPSE vocal plasticity 

分 类 号：Q95[生物学—动物学]