基于MOMP衣原体疫苗的研究进展  

Research progress on MOMP based chlamydia vaccine

作　　者：李勇浩 王宗保 王川 LI Yonghao;WANG Zongbao;WANG Chuan(Pathogenic Biology Institute,Hengyang Medical School,University of South China,Hengyang 421001,Hunan,China;Cell and Genetics Institute,Hengyang Medical School,University of South China,Hengyang 421001,Hunan,China)

机构地区：[1]南华大学衡阳医学院病原生物学研究所,湖南衡阳421001 [2]南华大学衡阳医学院细胞与遗传研究所,湖南衡阳421001

出　　处：《中南医学科学杂志》2023年第4期611-614,共4页Medical Science Journal of Central South China

基　　金：国家自然科学基金(31872643);湖南省自然科学基金(2021JJ40455)。

摘　　要：主要外膜蛋白(MOMP)是衣原体外膜复合物的主要成分,与衣原体的免疫原性、侵袭力及毒力密切相关,是衣原体的主要疫苗候选抗原。本文主要对MOMP及其相关疫苗研究进行综述,以望为靶向MOMP的新型或临床衣原体疫苗研发提供理论依据。Major outer membrane protein(MOMP)is the main component of Chlamydia extracorporeal membrane complex,which is closely related to the immunogenicity,invasiveness and virulence of Chlamydia,and is the main vaccine candidate antigen for Chlamydia.This paper mainly reviews the research progress on MOMP and its related vaccines in order to provide theoretical basis for the research and development of new clinical Chlamydia vaccines targeting MOMP.

关 键 词：衣原体 MOMP 衣原体疫苗 亚单位疫苗 DNA疫苗 纳米疫苗 

分 类 号：R374.2[医药卫生—病原生物学]