Transcriptome sequencing of black and white hair follicles in the giant panda  

作　　者：Yi ZHENG Yingmin ZHOU Yijie HUANG Haoqi WANG Haixiang GUO Bao YUAN Jiabao ZHANG 

机构地区：[1]Department of Laboratory Animals,Jilin Provincial Key Laboratory of Animal Model,Jilin University,Changchun,Jilin,China [2]Key Laboratory of SFGA on Conservation Biology of Rare Animals in The Giant Panda National Park,Dujiangyan,Sichuan,China

出　　处：《Integrative Zoology》2023年第3期552-568,共17页整合动物学（英文版）

基　　金：supported by the Open Project of Key Laboratory of SFGA on Conservation Biology of Rare Animals in the Giant Panda National Park(KLSFGAGP2020.009).

摘　　要：With the completion of the draft assembly of the giant panda genome sequence,RNA sequencing technology has been widely used in genetic research on giant pandas.We used RNA-seq to examine black and white hair follicle samples from adult pandas.By comparison with the giant panda genome,75963 SNP loci were labeled,2426 differentially expressed genes(DEGs)were identified,and 2029 new genes were discovered,among which 631 were functionally annotated.A cluster analysis of the DEGs showed that they were mainly related to the Wnt signaling pathway,ECM–receptor interaction,the p53 signaling pathway,and ribosome processing.The enrichment results showed that there were significant differences in the regulatory networks of hair follicles with different colors during the transitional stage of hair follicle resting growth,which may play a regulatory role in melanin synthesis during growth.In conclusion,our results provide new insights and more data support for research on the color formation in giant pandas.

关 键 词：giant panda hair color hair follicle TRANSCRIPTOME 

分 类 号：Q78[生物学—分子生物学]