The rough-toothed dolphin genome provides new insights into the genetic mechanism of its rough teeth  

作　　者：Xin HUANG Huizhong FAN Wenliang ZHOU Guang YANG Fuwen WEI 

机构地区：[1]CAS Key Laboratory of Animal Ecology and Conservation Biology,Institute of Zoology,Chinese Academy of Sciences,Beijing,China [2]University of Chinese Academy of Sciences,Beijing,China [3]Center for Evolution and Conservation Biology,Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou),Guangzhou,China

出　　处：《Integrative Zoology》2023年第4期601-615,共15页整合动物学（英文版）

基　　金：supported by the Ministry of Science and Technology of China(2022YFF1301601),and the PI Project of Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou)(GML2020GD0804 and GML2022GD0804).

摘　　要：The rough-toothed dolphin(Steno bredanensis)is characterized by having teeth covered infinely wrinkled vertical ridges,which is a general manifestation of amelogenesis imperfecta.The rough surfaces are hypothesized to be an evolutionary morphological trait of feeding adaptation to increase the dolphin’s grip on prey.Here,we assembled a rough-toothed dolphin genome and performed the comparative genomic analysis to reveal the genetic basis of the special enamel.Results showed that genes related to enamel development or dental diseases have undergone diver-sified adaptive changes that may shape the special enamel morphology of this dolphin species,including positive selection(CLDN19,PRKCE,SSUH2,and WDR72),rapid evolution(LAMB3),or unique amino acid substitutions(AMTN,ENAM,MMP20,and KLK4).Meanwhile,the historical demography of rough-toothed dolphin indicated several distinct populationfluctuations associated with climate change.The genome-wide heterozygosity of this dolphin is in the middle of all published data for cetaceans.Although the population is considerable,there may be population or subspecies differentiation,and with the global warming and the increasing disturbance of human activities,we should pay more attention to protection in the future.Together,our study brings new insights into the genetic mechanisms that may have driven the evolution of the special enamel morphology in rough-toothed dolphins and provides thefirst results of genetic heterozygosity and population historical dynamics of this species,which have important guiding implications for the conservation of this dolphin species.

关 键 词：adaptive evolution amelogenesis imperfecta CETACEANS GENOME rough-toothed dolphin 

分 类 号：Q78[生物学—分子生物学]