血清Vasohibin-1,TIMP-1对慢阻肺患者急性加重风险的预测价值分析  

Predictive value of serum Vasohibin-1 and TIMP-1 on the risk of acute exacerbation in invalids with chronic obstructive pulmonary disease

作　　者：何邦立 林亚发 符名勇 王建平 吴毓磊 Bang li;LIN Yafa;FU Mingyong;WANG Jianping;WU Yulei(Emergency Department,the Fourth People's Hospital of Haikou,Haikou Hainan 571100,China)

机构地区：[1]海口市第四人民医院急诊科,海南海口571100 [2]海口市第四人民医院重症病房,海南海口571100 [3]文昌市人民医院心内科,海南文昌571300

出　　处：《中国急救复苏与灾害医学杂志》2023年第7期897-900,904,共5页China Journal of Emergency Resuscitation and Disaster Medicine

基　　金：海南省卫生健康行业科研项目(编号:20A200306)。

摘　　要：目的分析血清血管生成抑制蛋白1(vasohibin-1)、金属蛋白酶组织抑制因子-1(TIMP-1)对慢性阻塞性肺疾病(COPD)患者急性加重风险的预测价值。方法以2020年3月—2021年3月经海口市第四人民医院确诊并进行治疗的86例COPD患者作为研究组,根据出院后1年内急性加重的次数分为急性加重风险组(32例)及无急性加重风险组(54例)。将同期来本院体检的60例健康人群作为对照组。所有纳入对象入院后均检测血清Vasohibin-1、TIMP-1水平,并进行组间比较。采用受试者工作特性(ROC)曲线分析血清Vasohibin-1、TIMP-1对COPD急性加重风险的预测价值,同时实施多因素Logistic的回归分析影响COPD急性加重风险的危险因素。结果研究组患者血清Vasohibin-1、TIMP-1水平均明显高于对照组(P<0.05);急性加重风险组患者血清Vasohibin-1、TIMP-1水平明显高于无急性加重风险组(P<0.05)。ROC曲线结果显示,血清Vasohibin-1曲线下面积为0.769,截断值506.52 ng/L,敏感度、特异度分别为94.12%、50.00%;TIMP-1曲线下面积为0.832,截断值272.36 ng/mL,敏感度、特异度分别为94.12%、61.11%;两者联合曲线下面积为0.921,敏感度、特异度分别为84.38%、87.04%。多因素Logistic回归分析结果显示,血清Vasohibin-1[OR(95%CI)=2.90(1.75~8.72)]、TIMP-1[OR(95%CI)=4.14(1.65~10.37)]均为影响COPD患者出现急性加重的危险因素(P<0.05)。结论血清Vasohibin-1、TIMP-1水平在COPD患者中均升高,并且与急性加重风险密切有关,可作为预测COPD患者出现急性加重风险的有效指标物。Objective To explore the predictive value of serum Vasohibin-1 and tissue inhibitor of metalloproteinase-1(TIMP-1)on the risk of acute exacerbation in invalids with chronic obstructive pulmonary disease(COPD).Methods A total of 86 COPD invalids diagnosed and treated in the Fourth People's Hospital of Haikou from March 2020 to March 2021 were selected as the research group,and were divided into acute exacerbation risk group(32 cases)and no acute exacerbation risk group(54 cases)according to the times of acute exacerbations within 1 year after discharge group.In addition,60 healthy people who came to our hospital for physical examination were selected as control group during the same period.Serum Vasohibin-1 and TIMP-1 levels were detected in all included subjects after admission,and compared between groups.The receiver operating characteristic(ROC)curve was used to analyze the predictive value of serum Vasohibin-1 and TIMP-1 on the risk of acute exacerbation of COPD,and multivariate Logistic regression was used to analyze the risk factors affecting the risk of acute exacerbation of COPD.Results The levels of serum Vasohibin-1 and TIMP-1 in research group were obvious higher than those in the control group(P<0.05).The levels of serum Vasohibin-1 and TIMP-1 in COPD invalids in the acute exacerbation risk group were obvious higher than non-acute exacerbation risk group(P<0.05).The ROC curve results showed that the area under the curve of serum Vasohibin-1 was 0.769,and the cut-off value was 506.52 ng/L,the sensitivity and specificity were 94.12%and 50.00%,respectively.The area under the curve of TIMP-1 was 0.832,and the cut-off value was 272.36 ng/mL,the sensitivity and specificity were 94.12%and 61.11%,respectively.The area under the combined curve was 0.921,and the sensitivity and specificity were 84.38%and 87.04%,respectively.The results of multivariate Logistic regression analysis showed that serum Vasohibin-1[OR(95%CI)=2.90(1.75~8.72)]and TIMP-1[OR(95%CI)=4.14(1.65~10.37)]were both risk factors for COPD invalids

关 键 词：血管生成抑制蛋白1(vasohibin-1) 基质金属蛋白酶组织抑制因子-1(TIMP-1) 慢性阻塞性肺疾病(COPD) 急性加重 风险因素 

分 类 号：R563[医药卫生—呼吸系统]