The effect of an adaptation to hypoxia on cardiac tolerance to ischemia/reperfusion  

作　　者：Natalia V.Naryzhnaya Leonid N.Maslov Ivan A.Derkachev Huijie Ma Yi Zhang NRajendra Prasad Nirmal Singh Feng Fu Jianming Pei Akpay Sarybaev Akylbek Sydykov 

机构地区：[1]Laboratory of Experimental Cardiology,Cardiology Research Institute,Tomsk National Research Medical Center,Russian Academy of Science,Tomsk,Tomsk Region 634012,Russia [2]Department of Physiology,Hebei Medical University,Shijiazhuang,Hebei 050017,China [3]Department of Biochemistry and Biotechnology,Faculty of Science,Annamalai University,Annamalainagar,Tamilnadu 608002,India [4]Department of Pharmaceutical Sciences and Drug Research,Punjabi University,Patiala,Punjabi 147002,India [5]Department of Physiology and Pathophysiology,National Key Discipline of Cell Biology,School of Basic Medicine,the Fourth Military Medical University,Xi'an,Shaanxi 710032,China [6]Department of Mountain and Sleep Medicine and Pulmonary Hypertension,National Center of Cardiology and Internal Medicine,Bishkek 720040,Kyrgyzstan [7]Kyrgyz-Indian Mountain Biomedical Research Center,Bishkek 720033,Kyrgyzstan [8]Department of Internal Medicine,Excellence Cluster Cardio-Pulmonary Institute(CPI),Member of the German Center for Lung Research(DZL),Justus Liebig University of Giessen,Giessen,Hessen 35392,Germany [9]Department of Mountain and Sleep Medicine and Pulmonary Hypertension,National Center of Cardiology and Internal Medicine,Bishkek 720040,Kyrgyzstan.

出　　处：《The Journal of Biomedical Research》2023年第4期230-254,共25页生物医学研究杂志（英文版）

基　　金：supported by the Russian Science Foundation grant 22-15-00048;The section dedicated to the role of kinases in the cardioprotective effect of CH is framed within the framework of state assignments 122020300042-4.

摘　　要：The acute myocardial infarction(AMI)and sudden cardiac death(SCD),both associated with acute cardiac ischemia,are one of the leading causes of adult death in economically developed countries.The development of new approaches for the treatment and prevention of AMI and SCD remains the highest priority for medicine.A study on the cardiovascular effects of chronic hypoxia(CH)may contribute to the development of these methods.Chronic hypoxia exerts both positive and adverse effects.The positive effects are the infarct-reducing,vasoprotective,and antiarrhythmic effects,which can lead to the improvement of cardiac contractility in reperfusion.The adverse effects are pulmonary hypertension and right ventricular hypertrophy.This review presents a comprehensive overview of how CH enhances cardiac tolerance to ischemia/reperfusion.It is an in-depth analysis of the published data on the underlying mechanisms,which can lead to future development of the cardioprotective effect of CH.A better understanding of the CH-activated protective signaling pathways may contribute to new therapeutic approaches in an increase of cardiac tolerance to ischemia/reperfusion.

关 键 词：HEART VESSELS infarct size ARRHYTHMIAS chronic hypoxia 

分 类 号：R542.2[医药卫生—心血管疾病]