7.5Fr一次性输尿管软镜改善肾内灌流量和降低肾内压的一项体外实验  

In vitro study of 7.5Fr disposable flexible ureteroscope for reducing intrarenal pressure and improving irrigation

作　　者：刘林虎 林乐德 陈吉祥 李虹[1] 王坤杰[1] LIU Linhu;LIN Lede;CHEN Jixiang;LI Hong;WANG Kunjie(Department of Urology,Institute of Urology,Laboratory of Urinary Stones and Reconstructive Urology,West China Hospital,Sichuan University,Chengdu,610041,China)

机构地区：[1]四川大学华西医院泌尿外科泌尿外科结石与修复重建实验室,成都610041

出　　处：《临床泌尿外科杂志》2023年第6期410-413,共4页Journal of Clinical Urology

摘　　要：目的比较国产7.5Fr一次性超细输尿管软镜与9.2Fr一次性输尿管软镜对肾内压及肾内灌注流量的影响。方法采用2颗利用CT三维重建数据进行3D打印的硅胶肾脏模型[肾盂漏斗夹角(infundibulopelvic angle,IPA)分别>90°和≤90°],在100 cmH2O的悬挂式生理盐水灌注下,分别置入10/12F、12/14F和14/16F输尿管鞘,使用生物信号采集装置分别测量肾脏模型上盏、中盏、下盏以及肾盂部分的肾内压,并计算分钟灌流率。结果使用7.5Fr软镜相较于9.2Fr软镜可以显著降低肾内压。使用10/12F、12/14F和14/16F输尿管鞘时,7.5Fr和9.2Fr软镜产生的肾盂内压分别为[(9.29±0.02)mmHg vs(25.11±0.35)mmHg]、[(0.80±0.03)mmHg vs(4.27±0.33)mmHg]和[(0.33±0.02)mmHg vs(0.06±0.06)mmHg]。在使用10/12F输尿管鞘的肾模型下盏,9.2Fr软镜在IPA≤90°和IPA>90°的模型中的肾内压分别达到了最高的45.71 mmHg和23.99 mmHg。而使用7.5Fr软镜时肾内压则维持较低水平(分别为3.73 mmHg和12.88 mmHg)。7.5Fr软镜较9.2Fr软镜显著增加了肾内灌流率。在使用10/12F、12/14F和14/16F输尿管鞘时,肾内灌流率分别为(36.0 mL/min vs 7.7 mL/min,P<0.001)、(44.3 mL/min vs 30.7 mL/min,P<0.001)和(47.7 mL/min vs 41.0 mL/min,P=0.013)。结论该7.5Fr超细一次性输尿管软镜具有降低肾内压和增加肾内灌流量的潜在优势,特别是在使用更细的输尿管鞘以及更小的肾盂漏斗角的应用场景中。Objective To compare the effects between 7.5Fr disposable flexible ureteroscope(f-URS)and 9.2Fr ureteroscope on intrarenal pressure and irrigation.Methods Two 3D printed silicone kidney models with infundibulopelvic angle(IPA)over and less than 90°were created using CT 3D reconstruction imaging data and were implanted with 10/12F,12/14F and 14/16F ureteral access sheathes under 100 cmH2O saline perfusion.The intrarenal pressure of upper,middle,lower calyces and renal pelvis in the model were measured respectively by probe puncture with a biological signal acquisition device,and the minute volume of irrigation was calculated.Results When using 10/12F,12/14F,and 14/16F ureteral access sheaths,the pressures produced by 7.5Fr and 9.2Fr f-URS in renal pelvis were([9.29±0.02]mmHg vs[25.11±0.35]mmHg),([0.80±0.03]mmHg vs[4.27±0.33]mmHg),and([0.33±0.02]mmHg vs[0.06±0.06]mmHg),respectively.In the lower calyx of the kidney model with IPA less than or greater than 90°and using a 10/12F ureteral access sheath,the intrarenal pressure reached 45.71 mmHg and 23.99 mmHg,respectively,when using a 9.2Fr ureteroscope.However,the use of a 7.5Fr ureteroscope maintained lower intrarenal pressures of 3.73 mmHg and 12.88 mmHg,respectively.The 7.5Fr ureteroscope significantly increased the irrigation rate compared to the 9.2Fr ureteroscope,with rates of(36.0 mL/min vs 7.7 mL/min,P<0.001),(44.3 mL/min vs 30.7 mL/min,P<0.001),and(47.7 mL/min vs 41.0 mL/min,P=0.013)observed when using 10/12F,12/14F,and 14/16F ureteral access sheaths,respectively.Conclusion This 7.5Fr disposable f-URS can decrease intrarenal pressure and increase irrigation,especially when used with narrower ureteral access sheaths and smaller IPA.

关 键 词：一次性输尿管软镜 肾内压 灌注流量 

分 类 号：R692[医药卫生—泌尿科学]