Coronaviruses RNA interacts with host miR-500a-5p and miR-501-5p to regulate multiple pathways  

作　　者：Qi Guo Linghui Tan Jiajia Pan Songfang Wu Jiansong Huang Fang Yu Jinghan Wang 

机构地区：[1]Department of Nephrology,The First Affiliated Hospital,School of Medicine Zhejiang University,Hangzhou,Zhejiang 310003,China [2]Zhejiang University School of Medicine,Hangzhou,Zhejiang 310003,China [3]Shanghai Xuhui Central Hospital/Zhongshan-Xuhui Hospital,Fudan University,Shanghai 200000,China [4]Department of Pathology,The First Affiliated Hospital,School of Medicine Zhejiang University,Hangzhou,Zhejiang 310003,China [5]Department of Hematology,The First Affiliated Hospital,School of Medicine Zhejiang University,Hangzhou,Zhejiang 310003,China

出　　处：《Genes & Diseases》2023年第2期385-388,共4页基因与疾病（英文）

摘　　要：The Coronavirus disease is the contagious disease. Clinical manifests vary from no symptoms, upper and lower respiratory tract infections, and even severe acute respiratory distress syndrome and multiple organs failure. Recently, three of new beta-coronaviruses have emerged to cause serious and widespread illness and death, such as the Severe Acute Respiratory Syndrome Coronaviruses (SARS-CoV), Middle East Respiratory Syndrome Coronaviruses (MERS-CoV), and 2019-nCoV (the causative pathogen of Coronavirus Disease 2019 (COVID-19). The COVID-19 is continuing to spread globally. However, the detailed molecular mechanisms have not yet been fully clarified. Since the similarity of the pathological features among 2019-nCoV, SARS-CoV and MERS-CoV, we could speculate the biological features of current COVID-19 by researching those of MERS-CoV and SARS-CoV. Therefore, we analyzed expression levels of miRNA and mRNA profiles of MERS-CoV, SARS-CoV and 2019-nCoV from five public GEO datasets (Table S1). As a result, we found 16 miRNAs potentially target a group of hub genes clustering together to tune the immune response. Notably, viral RNAs have the ability to sponge miR-500a-5p and miR-501-5p, indicating viral RNAs sequestering these two miRNAs to trigger genes expression and contribute to pathogenesis. We hope this study will pave the way to better understand 2019-nCoV pathogenesis and develop the innovative therapeutics.

关 键 词：MIR ORGANS SPONGE 

分 类 号：R563.1[医药卫生—呼吸系统]