利用NVP组分调控亲水增强型温敏性PNIPAAm共聚物  

Regulation of Thermoresponsive PNIPAAm Copolymers with Enhanced Hydrophilicity via NVP Moieties

作　　者：范晓光[1] 雷景胜 顾诗雅 冷旭 刘畅[1] 杨磊 FAN Xiaoguang;LEI Jingsheng;GU Shiya;LENG Xu;LIU Chang;YANG Lei(College of Engineering,Shenyang Agricultural University,Shenyang 110866,China;School of Petrochemical Engineering,Liaoning Petrochemical University,Fushun 113001,Liaoning,China)

机构地区：[1]沈阳农业大学工程学院,沈阳110866 [2]辽宁石油化工大学石油化工学院,辽宁抚顺113001

出　　处：《材料导报》2023年第15期230-236,共7页Materials Reports

基　　金：国家自然科学基金青年基金(21604034);辽宁省教育厅项目-面上项目(LJKZ0693);辽宁省教育厅一般科研项目(L2020015)。

摘　　要：聚N-异丙基丙烯酰胺(PNIPAAm)是目前在生物医药领域研究和应用最为广泛的一种温敏性聚合物。但PNIPAAm均聚物的温敏性能相对单一,且由其构建的终产物难以在较宽温度范围内通过改变温度发生整体体积或表面润湿性能转变,因此限制了其应用范围。为了扩展PNIPAAm的应用领域,设计可以调控特别是提升PNIPAAm基材最低临界溶液温度(LCST)的温敏性聚合物十分必要。鉴于此,本研究将亲水性N-乙烯基吡咯烷酮(NVP)引入温敏性聚合物分子骨架,同时利用共聚物的反应基团将P(NIPAAm-co-NVP)共聚物聚合接枝于铂片表面从而形成共聚物膜。衰减全反射-傅里叶变换红外光谱(ATR-FTIR)、核磁共振氢谱(1H-NMR)和凝胶渗透色谱(GPC)的鉴定结果表明各单体间的共聚反应均按预定方案进行,且可显著提升NVP在聚合过程的参与率;动态光散射(DLS)和静态接触角数据、扫描电子显微镜(SEM)图像均证明可以利用NVP组分提升P(NIPAAm-co-NVP)共聚物的LCST,从而获得亲水增强型的温敏性共聚物膜,该膜可用于药物控制释放和非侵害性细胞收获等。Poly(N-isopropylacrylamide)(PNIPAAm)is one of the most widely studied and applied thermoresponsive polymers in biomedical fields.However,the temperature sensitivity of PNIPAAm homopolymers is relatively narrow,and the final products constructed from PNIPAAm homopolymers are difficult to change the overall volume or surface wettability under a wide temperature range by changing temperature,so their applications are limited.To expand the applications of PNIPAAm,it is necessary to design the thermoresponsive polymers with the adjustable lower critical solution temperature(LCST),especially for the enhanced LCST.Hence,hydrophilic N-vinylpyrrolidone(NVP)monomers were introduced into the molecular chains of thermoresponsive polymers,and P(NIPAAm-co-NVP)copolymers were polymerized and grafted onto the surfaces of platinum plates via the reactive groups of the copolymers to form copolymer films in this study.The results of attenuated total reflection-Fourier transform infrared spectroscopy(ATR-FTIR),nuclear magnetic resonance(1H-NMR)and gel permeation chromatography(GPC)showed that the copolymerization of each kind of monomer was carried out in predetermined way,and the participation rate of NVP in the polymerization process was significantly increased.Dynamic light scattering(DLS)and static contact angle data,scanning electron microscope(SEM)images confirmed that the LCST of P(NIPAAm-co-NVP)copolymers had been enhanced by addition of NVP moieties,so as to obtain thermoresponsive copolymer films with enhanced hydrophilicity,which could be used for drug controlled release and non-invasive cell harvest.

关 键 词：聚N-异丙基丙烯酰胺(PNIPAAm) N-乙烯基吡咯烷酮(NVP) 最低临界溶液温度(LCST) 自由基聚合法 亲水性 

分 类 号：O633[理学—高分子化学]