三类射血分数保留的心力衰竭患者一般临床特征及血清炎症因子水平对比分析  

Contrastive analysis on general clinical features and serum inflammatory factor level in three types ejection fraction preserved heart failure patients

作　　者：何显菁[1] 包强 詹源胜[1] 陈华昌 吴杏起 HE Xianjing;BAO Qiang;ZHAN Yuansheng;CHEN Huachang;WU Xingqi(Department of Cardiovascular Medicine,Beihai People’s Hospital,Beihai 536000,China)

机构地区：[1]北海市人民医院心血管内科,广西北海536000

出　　处：《医药前沿》2023年第13期21-24,共4页Journal of Frontiers of Medicine

基　　金：北海市科技局基金项目(2020165015)。

摘　　要：目的:对比分析三类射血分数保留的心力衰竭(HFpEF)患者一般临床特征及血清炎症因子TNF-α、IL-6、IL-1β、CRP的水平。方法:随机选取2021年7月—2022年12月北海市人民医院心血管内科收治的三类HFpEF患者共107例,按照葛氏分型分为血管疾病相关HFpEF组(HFpEF-1组)40例,右心和肺相关HFpEF组(HFpEF-3组)29例,瓣膜和节律相关HFpEF组(HFpEF-4组)38例。比较各组患者一般临床特征及炎症因子TNF-α、IL-6、IL-1β、CRP的水平。结果:①三组患者年龄、性别比较,差异无统计学意义(P>0.05)。HFpEF-1组患者体质指数大于HFpEF-3及HFpEF-4组(P<0.05);HFpEF-4组患者房颤占比高于HFpEF-1组(P<0.05);HFpEF-3组心功能Ⅱ级患者占比低于HFpEF-1及HFpEF-4组(P<0.05)。②三组患者NT-proBNP、HCY、D-dimer、WBC、NEU%、LYMPH%、ALT、BUN、Cr等各项指标比较,差异均无统计学意义(P>0.05)。HFpEF-3组患者UA大于HFpEF-1组(P<0.05)。③三组患者LVESD、LVEDD、IVSD、EF等各项指标比较,差异均无统计学意义(P>0.05)。HFpEF-3组LAD、RVD均大于HFpEF-1组和HFpEF-4组(P<0.05)。④三组患者TNF-α、IL-6、IL-1β、CRP水平比较,差异均无统计学意义(P>0.05)。结论:HFpEF-1组患者体质指数相对大;HFpEF-4组患者房颤发生率相对高;HFpEF-3组患者心功能相对更差,左心房内径及右心室内径更大,更容易伴随尿酸升高。三组患者体内炎症因子水平的差异无统计学意义。Objective To contrastively analyze the general clinical features and serum inflammatory factor level in three types ejection fraction preserved heart failure patients.Methods From July 2021 to December 2022,a total of 107 three types ejection fraction preserved heart failure patients were selected in the Department of Cardiovascular Medicine,Beihai People’s Hospital,and they were divided into vascular disease related HFpEF group(HFpEF-1 group,n=40),right heart and lung related HFpEF group(HFpEF-3 group,n=29),and valve and rhythm related HFpEF group(HFpEF-4 group,n=38)according to Ge’s typing.General clinical features and serum TNF-α,IL-6,IL-1β,CRP level were compared in the three groups.Results①There was no statistically significant difference in age and male ratio in the three groups(P>0.05).BMI of HFpEF-1 group was higher than that in HFpEF-3 and HFpEF-4 groups(P<0.05).Atrial fibrillation ratio of HFpEF-4 group was higher than that of HFpEF-1 group(P<0.05).NYHA cardiac function gradeⅡratio of HFpEF-3 group was lower than that in HFpEF-1 and HFpEF-4 groups(P<0.05).②There was no statistically significant difference in NT-proBNP,HCY,D-dimer,WBC,NEU%,LYMPH%,ALT,BUN and Cr in the three groups(P>0.05).UA of HFpEF-3 group was higher than that in HFpEF-1 group(P<0.05).③There was no statistically significant difference of LVESD,LVEDD,IVSD and EF in the three groups(P>0.05).LAD and RVD of HFpEF-3 group was higher than that of HFpEF-1 and HFpEF-4 group(P<0.05).④There was no statistically significant difference of TNF-α,IL-6,IL-1βand CRP level in the three groups(P>0.05).Conclusion HFpEF-1 group patient has higher BMI;HFpEF-4 group patient has higher atrial fibrillation incidence;HFpEF-3 group patient has worse cardiac function,bigger LAD and RVD,higher UA level.There was no statistically significant difference of inflammatory factor level in the three group patients.

关 键 词：射血分数保留的心力衰竭 一般临床特征 TNF-Α IL-6 IL-1Β CRP 

分 类 号：R541.6[医药卫生—心血管疾病]