调肝扶脾法治疗非重型免疫性血小板减少症的临床疗效观察  

Observation on the Clinical Curative Effect of Regulating the Liver and Supporting the Spleen in the Treatment of Non-severe Immune Thrombocytopenia

作　　者：郑荣 黄建栩 李达[2] 吴建伟 Zheng Rong;Huang Jian-xu;Li Da;Wu Jian-wei(Department of Hematology1,Jiangmen Hospital of Traditional Chinese Medicine Affiliated to Jinan University,Wuyi Hospital of Traditional Chinese Medicine,Jiangmen 529000,Guangdong Province,China;Department of Hematology2,Guangdong Provincial Hospital of Traditional Chinese Medicine,Guangzhou 510000,Guangdong Province,China)

机构地区：[1]暨南大学附属江门中医院,江门市五邑中医院血液科1,广东江门529000 [2]广东省中医院血液科2,广东广州510000

出　　处：《中外医药研究》2023年第6期70-72,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

基　　金：广东省江门市科技局2020年医疗卫生科技计划项目(编号:2020YLB018)。

摘　　要：目的:分析调肝扶脾法治疗非重型免疫性血小板减少症(ITP)的临床疗效。方法:选取2020年5月—2021年5月暨南大学附属江门中医院门诊就诊的非重型ITP患者30例作为研究对象,14例以“调肝扶脾”核心方为主辨证加减治疗(单纯中药治疗),16例在原有常规西药治疗的基础上加用“调肝扶脾”核心方治疗(中西药联合治疗)。比较治疗前后症状(疲劳、出血)改善状况、血小板计数水平变化、激素减撤情况、不良反应发生情况。结果:治疗1、3个月后,30例患者慢性病治疗功能评估-疲劳量表评分、ITP出血评分量表评分均低于治疗前,血小板计数水平高于治疗前,差异有统计学意义(P<0.05);治疗3个月后,血小板计数水平高于治疗1个月后,差异有统计学意义(P<0.05)。5例激素依赖患者中,4例患者联合服用调肝扶脾核心方治疗后可逐渐减撤激素。3例激素依赖患者服用中药后激动、失眠等激素不良反应显著减少。结论:调肝扶脾法治疗非重型ITP的临床疗效显著,能够改善患者疲劳、出血症状,并有助于克服激素依赖,降低不良反应发生风险,改善患者预后。Objective:To analyze the clinical curative effect of regulating the liver and supporting the spleen in the treatment of non-severe immune thrombocytopenia(ITP).Methods:From May 2020 to May 2021,thirty patients with non-severe ITP who visited the Jiangmen Hospital of Traditional Chinese Medicine affiliated to Jinan University were selected as the research objects.For fourteen cases,the core prescription of"regulating the liver and supporting the spleen"was used as the main treatment(Chinese medicine treatment only),and in sixteen cases,the core prescription of"regulating the liver and supporting the spleen"was added to the original conventional western medicine treatment(combined Chinese and Western medicine treatment).The improvement of symptoms(fatigue,bleeding),the change of platelet count level,the reduction and withdrawal of hormones,and the occurrence of adverse reactions were compared before and after treatment.Results:After 1 and 3 months of treatment,the scores of chronic disease treatment function assessment-fatigue scale and ITP bleeding scale of 30 patients were lower than those before treatment,and the platelet count level was higher than before treatment,the difference was statistically significant(P<0.05).After 3 months of treatment,the level of platelet count was higher than that after 1 month of treatment,and the difference was statistically significant(P<0.05).Among the five hormone-dependent patients,four patients could gradually withdraw their hormones after being treated with regulating the liver and supporting the spleen formula.After taking traditional Chinese medicine,three hormone-dependent patients had significantly reduced hormone adverse reactions such as agitation and insomnia.Conclusion:The method of regulating the liver and supporting the spleen has a significant clinical effect in the treatment of nonsevere ITP.It can improve the fatigue and bleeding symptoms of patients,help overcome hormone dependence,reduce the risk of adverse reactions,and improve the prognosis of patients.

关 键 词：非重型免疫性血小板减少症 调肝扶脾法 激素 

分 类 号：R47[医药卫生—护理学]