合成卡西酮类新精神活性物质4-F-3-Me-ɑ-PVP的检测  

Identification of a new psychoactive substance of synthetic cathinone named 4-F-3-Me-ɑ-PVP

作　　者：王跨陡 袁晓亮 何思阳[1] 盛振海 刘文斌 曹芳琦 WANG Kua-dou;YUAN Xiao-liang;HE Si-yang;SHENG Zhen-hai;LIU Wen-bin;CAO Fang-qi(Institute of Forensic Science of Shanghai Public Security Bureau,Shanghai 200083,China;Shanghai Research Institute of Criminal Science and Technology,Shanghai 200083,China)

机构地区：[1]上海市公安局物证鉴定中心上海市现场物证重点实验室,上海200083 [2]上海市刑事科学技术研究院上海市现场物证重点实验室,上海200083

出　　处：《药物分析杂志》2023年第6期950-956,共7页Chinese Journal of Pharmaceutical Analysis

基　　金：上海市科委科技计划项目(212dz200200)。

摘　　要：目的:建立合成卡西酮类新精神活性物质4-F-3-Me-ɑ-PVP的检测鉴定方法。方法:检材分别用GC-MS、UPLC-QTOF/MS)(溶剂为甲醇)及核磁共振波谱仪(溶剂为氘代甲醇)检测。结果:检材经UPLC-QTOF MS实测的精确质量数[M+H]^(+)为m/z 264.17592,GC-MS检测得到的质谱主要特征离子分别为:m/z 126(基峰)、109、137,经GC-MS和UPLC-QTOF/MS数据分析,得到了匹配度很高的2种同分异构体物质4-F-3-Me-ɑ-PVP和3-F-4-Me-ɑ-PVP,经进一步用NMR对其测定并解析结构,确认了检材为新的合成卡西酮类新精神活性物质4-F-3-Me-ɑ-PVP。结论:本研究建立的多技术联合方法能用于4-F-3-Me-ɑ-PVP的检测鉴定。该方法直观、明确、可靠、实用。Objective:To establish a method for the detection and identification of a new psychoactive substance of synthetic cathinone 4-F-3-Me-ɑ-PVP.Method:The samples were analyzed by GC-MS,UPLC-QTOF MS(solvent was methanol),and nuclear magnetic resonance spectrometry(solvent was deuterated methanol).Result:According to the UPLC-QTOF-MS data,the accurate protonated molecule[M+H]^(+)was m/z 264.17592(C_(16)H_(23)FNO^(+)).The main characteristic ions by GC-MS were:m/z 126(base peak),109,137.By the GC-MS and UPLC-QTOF MS data,the compounds could be one of two isomer substances 4-F-3-Me-ɑ-PVP and 3-F-4-Me-ɑ-PVP.After further structure analysis by NMR,the sample was confirmed as a new psychoactive substance of synthetic cathinone 4-F-3-Me-ɑ-PVP.Conclusion:The multi-technique combined method established in this study can be used for the detection and identification of 4-F-3-Me-ɑ-PVP.The method is intuitive,clear,reliable and practical.

关 键 词：药物分析 结构鉴定 合成卡西酮类 气相色谱-质谱 超高效液相色谱/离子淌度-串联四极杆飞行时间质谱 核磁共振波谱 新精神活性物质(new psychoactive substances NPS)4-F-3-Me-ɑ-PVP 

分 类 号：R917[医药卫生—药物分析学]