抗-I抗体导致的配血困难1例及输血策略  

One case of difficulty in matching blood and transfusion strategy caused by anti-I antibody

作　　者：张瑞宁 李艳[1] 张瑜[1] 吴继博 万春晶 王宝燕[1] ZHANG Ruining;LI Yan;ZHANG Yu;WU Jibo;WAN Chunjing;WANG Baoyan(Department of Blood Transfusion,First Affiliated Hospital of Xi'an Jiaotong University,Xi'an,710061,China)

机构地区：[1]西安交通大学第一附属医院输血科,西安710061

出　　处：《临床血液学杂志》2023年第6期445-447,共3页Journal of Clinical Hematology

基　　金：西安交通大学第一附属医院科研发展基金(No:2020ZYTS-23)。

摘　　要：目的:对1例抗I抗体引起的血型正反定型不符及交叉配血困难的患者进行回顾性分析。方法:采用免疫血清学方法对患者样本进行血型鉴定,同步进行不规则抗体筛查、交叉配血及效价检测,并进一步采用新生儿细胞检测血型反定型,不规则抗体鉴定。结果:患者血清中存在抗IgM-I抗体,效价为16,导致血型正反定型不一致及交叉配血困难。结论:在对患者血标本进行输血相容性检测时,如出现意外凝集,应对标本做进一步不规则抗体筛选及特异性鉴定,确定抗体类型,评估患者后选择最佳的输血策略。Objective To retrospectively analyze a patient with anti-I antibody causing mismatch between positive and negative blood type and difficulty in cross-matching blood group.Methods Blood group identification was carried out by immunoserology,irregular antibody screening,cross matching and titer detection were carried out simultaneously,and blood group reverse typing and irregular antibody identification were further carried out by neonatal cells.Results The anti IgM-I antibody was found in the serum of the patients,and the titer was 16.Conclusion In the case of accidental agglutination,irregular antibody screening and specificity identification should be performed to determine the type of antibody,and the optimal transfusion strategy should be selected after evaluation of the patient.

关 键 词：抗-I抗体 血型鉴定 交叉配血 

分 类 号：R457.1[医药卫生—治疗学]