The bibenzyl derivatives of Dendrobium officinale prevent UV-B irradiation induced photoaging via SIRT3  

作　　者：Ding-kang Chen Hui-yan Shao Liu Yang Jiang-miao Hu 

机构地区：[1]State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650201,China [2]R&D Center of Dr.Plant,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650201,China [3]University of Chinese Academy of Science,Beijing 100049,China

出　　处：《Natural Products and Bioprospecting》2022年第1期1-11,共11页应用天然产物（英文）

基　　金：supported by Biological Resources Programme,Chinese Academy of Sciences (Grant No.KFJ-BRP-007-019);National Natural Science Foundation of China (No.32170407) and Beijing DR PLANT Biotechnology Co.,Ltd.

摘　　要：Dendrobium officinale is a valuable medicinal herb that is widely used in traditional Chinese medicine.The chemical constituents of D.officinale have attracted much attention and a large number of compounds have been reported including many bibenzyl derivatives.13 bibenzyl derivatives from D.officinale were sent for molecular docking,sur-face plasmon resonance(SPR)assay and after detection of Mn-SOD and SIRT3 activities in or not in HaCaT cells,it was concluded that bibenzyl derivatives did not directly activate Mn-SOD but promoted SIRT3 proteins.In addition,HaCaT cells were irradiated with UV-B to induce an oxidative stress model in vitro to further verify the effect of bibenzyl derivatives.The results show that bibenzyl derivatives could directly bind to SIRT3,enhance the deacetylation and then activate Mn-SOD,so as to protect UV-B induced skin photoaging.

关 键 词：Dendrobium officinale Bibenzyl derivatives Skin photoaging Oxidative stress SIRT3 

分 类 号：O62[理学—有机化学]