Structural derivatization strategies of natural phenols by semi-synthesis and total-synthesis  

作　　者：Ding Lin Senze Jiang Ailian Zhang Tong Wu Yongchang Qian Qingsong Shao 

机构地区：[1]State Key Laboratory of Subtropical Silviculture,Zhejiang A&F University,Hangzhou 311300,China [2]Zhejiang Provincial Key Laboratory of Resources Protection and Innovation of Traditional Chinese Medicine,Zhejiang A&F University,Hangzhou 311300,China

出　　处：《Natural Products and Bioprospecting》2022年第1期78-106,共29页应用天然产物（英文）

基　　金：supported by National Training Program of Innovation and Entrepreneurship for Undergraduates (202101341012);Talent Startup Project of Zhejiang A&F University Scientific Research and Development Fund (2034020154).

摘　　要：Structural derivatization of natural products has been a continuing and irreplaceable source of novel drug leads.Natural phenols are a broad category of natural products with wide pharmacological activity and have offered plenty of clinical drugs.However,the structural complexity and wide variety of natural phenols leads to the difficulty of structural derivatization.Skeleton analysis indicated most types of natural phenols can be structured by the combina-tion and extension of three common fragments containing phenol,phenylpropanoid and benzoyl.Based on these fragments,the derivatization strategies of natural phenols were unified and comprehensively analyzed in this review.In addition to classical methods,advanced strategies with high selectivity,efficiency and practicality were empha-sized.Total synthesis strategies of typical fragments such as stilbenes,chalcones and flavonoids were also covered and analyzed as the supplementary for supporting the diversity-oriented derivatization of natural phenols.

关 键 词：Natural phenols Structural derivatization Common fragments Total synthesis 

分 类 号：O62[理学—有机化学]