Lignans and sesquiterpenoids from the stems of Schisandra bicolor var. tuberculata  

作　　者：Shui-Mei Zhang Kun Hu Xiao-Nian Li Han-Dong Sun Pema-Tenzin Puno 

机构地区：[1]State Key Laboratory of Phytochemistry and Plant Resources in West China,Yunnan Key Laboratory of Natural Medicinal Chemistry,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650201,People’s Republic of China [2]University of Chinese Academy of Sciences,Beijing 10039,People’s Republic of China

出　　处：《Natural Products and Bioprospecting》2022年第1期256-264,共9页应用天然产物（英文）

基　　金：supported financially by the National Natural Science Foundation of China (No.81903520).

摘　　要：A pair of new tetrahydrofuran lignan enantiomers,(±)-schibiculatin A[(±)-1],a new enedione lignan,schibiculatin B(2),two new cadinane-type sesquiterpenoids,schibiculatins C(3)and D(4),along with two known seco-cadinane-type sesquiterpenoids(5 and 6)and seven known miscellaneous lignans(7-13)were isolated from the stems of Schisandra bicolor var.tuberculata.The structures of 1-4 were elucidated by comprehensive analysis of their spectro-scopic data,quantum chemical calculations,as well as single-crystal X-ray diffraction.A few isolated compounds were tested for their protective activities against corticosterone-induced apoptosis in PC12 cells.Among them,compounds 5 and 6 showed moderate activities.

关 键 词：Schisandra bicolor var.tuberculata Cadinane-type sesquiterpenoids Lignans Quantum chemical calculation 

分 类 号：O62[理学—有机化学]