Chemistry and bioactivities of natural steroidal alkaloids  

作　　者：Mei-Ling Xiang Bin-Yuan Hu Zi-Heng Qi Xiao-Na Wang Tian-Zhen Xie Zhao-Jie Wang Dan-Yu Ma Qi Zeng Xiao-Dong Luo 

机构地区：[1]Key Laboratory of Medicinal Chemistry for Natural Resource,Ministry of Education,Yunnan Provincial Center for Research&Development of Natural Products,School of Chemical Science and Technology,Yunnan University,Kunming 650091,People’s Republic of China [2]State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650201,People’s Republic of China

出　　处：《Natural Products and Bioprospecting》2022年第1期310-359,共50页应用天然产物（英文）

基　　金：the National Natural Science Foundation of China (32170405);Yunnan Science and Technology Project (202105AE160006,2019FY003004) for partial financial support.

摘　　要：Steroidal alkaloids possess the basic steroidal skeleton with a nitrogen atom in rings or side chains incorporated as an integral part of the molecule.They have demonstrated a wide range of biological activities,and some of them have even been developed as therapeutic drugs,such as abiraterone acetate(Zytiga®),a blockbuster drug,which has been used for the treatment of prostate cancer.Structurally diverse natural steroidal alkaloids present a wide spectrum of biological activities,which are attractive for natural product chemistry and medicinal chemistry communities.This review comprehensively covers the structural classification,isolation and various biological activities of 697 natural steroidal alkaloids discovered from 1926 to October 2021,with 363 references being cited.

关 键 词：Steroidal alkaloids CHEMISTRY BIOACTIVITIES SOLANACEAE LILIACEAE APOCYNACEAE Buxaceae 

分 类 号：O62[理学—有机化学]