New seco-anthraquinone glucoside from the roots of Rumex crispus  

作　　者：Yong-Xiang Li Na Li Jing-Juan Li Man Zhang Hong-Tao Zhu Dong Wang Ying-Jun Zhang 

机构地区：[1]State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650204,People’s Republic of China [2]University of Chinese Academy of Sciences,Beijing 100049,People’s Republic of China [3]Yunnan Key Laboratory of Natural Medicinal Chemistry,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650201,People’s Republic of China.

出　　处：《Natural Products and Bioprospecting》2022年第1期418-426,共9页应用天然产物（英文）

基　　金：supported by Ministry of Science and Technology of the People’s Republic of China,2021YFE0103600.

摘　　要：A new seco-anthraquinone,crispuside A(1),and three new 3,4-dihydronaphthalen-1(2H)-ones,napthalenones A-C(2-4),were isolated from the roots of Rumex crispus L.,along with 10 known anthraquinones(6-14)and naph-thalenone(5).Their structures were fully determined by extensive spectroscopic analyses,including ECD,and X-ray crystallography in case of compound 5,whose absolute configuration was determined for the first time.The isolates 1,6-14 were evaluated for their anti-inflammatory and anti-fungal activity against three skin fungi,e.g.,Epidermophyton floccosum,Trichophyton rubrum,and Microsporum gypseum.Most of the isolates showed weak anti-fungal and anti-inflammatory activity.Only compound 9 exhibited obvious anti-fungal activity against E.floccosum(MIC_(50)=2.467±0.03μM)and M.gypseum(MIC_(50)=4.673±0.077μM),while the MIC_(50)values of the positive control terbinafine were 1.287±0.012 and 0.077±0.00258μM,respectively.The results indicated that simple emodin type anthraquinone is more potential against skin fungi than its oxyglucosyl,C-glucosyl and glycosylated seco analogues.

关 键 词：POLYGONACEAE Rumex crispus L. Anthranoids Anti-fungal activity 

分 类 号：O62[理学—有机化学]