Tetra-,penta-,and hexa-nor-lanostane triterpenes from the medicinal fungus Ganoderma australe  

作　　者：Lin Zhou Subiy Akbar Meng-Xi Wang He-Ping Chen Ji-Kai Liu 

机构地区：[1]School of Pharmaceutical Sciences,South-Central Minzu University,430074 Wuhan,China

出　　处：《Natural Products and Bioprospecting》2022年第1期505-514,共10页应用天然产物（英文）

基　　金：National Natural Science Foundation of China (grant numbers 21961142008,22177138) for fundings.

摘　　要：Chemical investigation on the medicinal fungus Ganoderma australe led to the identification of ten new nor-lanostane triterpenes,namely two hexa-nor ones,ganoaustratetraenones A(1)and B(2),five penta-nor ones,ganoaustraldehydes A-E(3-7),and three tetra-nor ones ganoaustrenoic acids A-C(8-10).The chemical structures along with the absolute configurations were determined by extensive spectroscopic analysis of 1D&2D NMR and HRESIMS data.The postulated biosynthesis pathways of these compounds were proposed.Ganoaustraldehydes A(3)and B(4)showed moderate inhibition against nitric oxide production in RAW264.7 macrophage cells with the respec-tive IC_(50) values of 32.5,34.2μM(the IC_(50) of positive control pyrrolidine dithiocarbamate was 20.0μM).

关 键 词：BASIDIOMYCETE Ganoderma australe Nor-lanostane Structural determination Anti-NO production 

分 类 号：O62[理学—有机化学]