坏死性凋亡与铁死亡在急性肾损伤中的作用机制研究进展  

Research progress on the mechanism of necrotic apoptosis and ferroptosis in acute kidney injury

作　　者：王书琦(综述) 武卫东(审校)[1] Wang Shuqi;Wu Weidong(The Third Hospital of Shanxi Medical University,Shanxi Province,Taiyuan 030032,China)

机构地区：[1]山西医科大学第三医院,太原030032

出　　处：《疑难病杂志》2023年第7期772-775,781,共5页Chinese Journal of Difficult and Complicated Cases

基　　金：山西省科技厅面上自然基金项目(201901D111417)。

摘　　要：急性肾损伤(AKI)是世界范围内发病率最高的临床疾病之一,其特点是肾功能迅速恶化,并进一步引发代谢废物和毒素的积聚。现在越来越多的证据表明,坏死性凋亡和铁死亡是AKI的主要病理机制之一。文章就AKI中坏死性凋亡及铁死亡的定义、主要生化机制、主要调节因子及相关研究进展作一系统综述。Acute kidney injury(AKI)is one of the clinical diseases with the highest incidence rate in the world,characterized by rapid deterioration of renal function and further accumulation of metabolic wastes and toxins.Now more and more evidences show that necrotic apoptosis and ferroptosis are one of the main pathological mechanisms of AKI.This article reviews the definition,main biochemical mechanism,main regulatory factors and related research progress of necrotic apoptosis and Ferroptosis in AKI.

关 键 词：急性肾损伤 坏死性凋亡 铁死亡 

分 类 号：R692[医药卫生—泌尿科学]