参芪地黄汤加减联合罗沙司他治疗慢性肾脏病非透析肾性贫血临床研究  

Clinical Study on Modified Shenqi Dihuang Decoction Combined with Roxadustat for Renal Anemia in Non-Dialysis Chronic Kidney Disease

作　　者：沈娟惠 姜建平 SHEN Juanhui;JIANG Jianping

机构地区：[1]浙江省荣军医院老年科,浙江嘉兴314000

出　　处：《新中医》2023年第12期1-5,共5页New Chinese Medicine

摘　　要：目的:观察参芪地黄汤加减联合罗沙司他治疗慢性肾脏病非透析肾性贫血脾肾气虚证的临床疗效。方法:将94例慢性肾脏病非透析肾性贫血脾肾气虚证患者按随机数字表法分为对照组和观察组,每组47例。对照组予以罗沙司他治疗,观察组予以参芪地黄汤加减联合罗沙司他治疗,2组均治疗8周。比较2组临床疗效,治疗前后血红蛋白、红细胞计数、铁代谢指标水平,以及不良反应发生率。结果:治疗后,观察组临床疗效总有效率95.74%,高于对照组82.98%(P<0.05)。2组血红蛋白、红细胞计数水平均较治疗前升高(P<0.05),观察组血红蛋白、红细胞计数水平均高于对照组(P<0.05)。2组血清铁蛋白、铁离子、转铁蛋白水平均较治疗前升高(P<0.05),观察组血清铁蛋白、铁离子、转铁蛋白水平均高于对照组(P<0.05)。治疗期间,观察组不良反应发生率6.38%,与对照组10.64%比较,差异无统计学意义(P>0.05)。结论:与单独使用罗沙司他治疗比较,参芪地黄汤加减联合罗沙司他治疗慢性肾脏病非透析肾性贫血脾肾气虚证能提高疗效,改善患者的贫血状况,纠正铁代谢异常,安全性好。Objective:To observe the clinical effect of modified Shenqi Dihuang Decoction combined with Roxadustat for renal anemia in non-dialysis chronic kidney disease with spleen-kidney qi deficiency syndrome.Methods:A total of 94 cases of patients with renal anemia in non-dialysis chronic kidney disease with spleen-kidney qi deficiency syndrome were divided into the control group and the observation group according to the random number table method,with 47 cases in each group.The control group was treated with Roxadustat,and the observation group was additionally treated with modified Shenqi Dihuang Decoction based on the treatment of the control group.Both groups were treated for 8 weeks.Levels of hemoglobin,red blood cell count,and indexes of iron metabolism before and after treatment,clinical effects,and the incidence of adverse reactions were compared between the two groups.Results:After treatment,the total clinical effective rate was 95.74%in the observation group,higher than that of 82.98%in the control group(P<0.05).Levels of hemoglobin and red blood cell count in the two groups were increased when compared with those before treatment(P<0.05),and the above 2 levels in the observation group were higher than those in the control group(P<0.05).The levels of serum ferritin,iron ions,and transferrin in the two groups were increased when compared with those before treatment(P<0.05),and the 3 levels in the observation group were higher than those in the control group(P<0.05).During treatment,the incidence of adverse reactions was 6.38%in the observation group and 10.64%in the control group,there being no significant difference being found in the comparison between the two groups(P>0.05).Conclusion:Compared with the simple use of Roxadustat alone,the additional application with modified Shenqi Dihuang Decoction can enhance the curative effect in the treatment of renal anemia in non-dialysis chronic kidney disease with spleen-kidney qi deficiency syndrome,and can improve the anemia status of patients and correct the abnor

关 键 词：非透析肾性贫血 慢性肾脏病 脾肾气虚证 参芪地黄汤 罗沙司他 血红蛋白 红细胞计数 铁代谢 

分 类 号：R692[医药卫生—泌尿科学]