肾衰宁胶囊对维持性血液透析患者肠黏膜屏障功能、微炎症状态的影响  

Effects of Shenshuaining Capsules on Intestinal Mucosal Barrier Function and Microinflammatory Status in Patients with Maintenance Hemodialysis

作　　者：张佳佳 许杨 秦璐璐 ZHANG Jiajia;XU Yang;QIN Lulu

机构地区：[1]灵宝市第一人民医院肾脏内科(血液净化中心),河南灵宝472500 [2]灵宝市第一人民医院心血管二病区,河南灵宝472500 [3]灵宝市第一人民医院内分泌科,河南灵宝472500

出　　处：《新中医》2023年第12期76-80,共5页New Chinese Medicine

摘　　要：目的:观察肾衰宁胶囊对维持性血液透析患者肠黏膜屏障功能、微炎症状态的影响。方法:纳入104例慢性肾功能衰竭行维持性血液透析患者为研究对象,按随机数字表法分为治疗组与对照组各52例。对照组给予维持性血液透析治疗,治疗组在维持性血液透析治疗期间应用肾衰宁胶囊治疗。治疗3个月,比较2组临床疗效、肾功能、肠黏膜屏障功能及微炎症状态。结果:治疗组总有效率为94.23%,对照组为78.85%,2组比较,差异有统计学意义(P<0.05)。治疗前,2组血肌酐(SCr)、尿素氮(BUN)、估算肾小球滤过率(eGFR)水平比较,差异无统计学意义(P>0.05)。治疗后,治疗组SCr、BUN水平均较本组治疗前及对照组降低(P<0.05),eGFR水平较本组治疗前及对照组升高(P<0.05);对照组SCr、BUN、eGFR水平治疗前后比较,差异无统计学意义(P>0.05)。治疗前,2组D-乳酸、血清内毒素(ET)、二氨氧化酶(DAO)水平比较,差异无统计学意义(P>0.05)。治疗后,治疗组D-乳酸、ET、DAO水平均低于本组治疗前及对照组(P<0.05);对照组上述3项肠黏膜屏障功能指标治疗前后比较,差异无统计学意义(P>0.05)。治疗前,2组血清超敏C-反应蛋白(hs-CRP)、同型半胱氨酸(Hcy)水平比较,差异无统计学意义(P>0.05)。治疗后,治疗组hs-CRP、Hcy水平均较本组治疗前及对照组降低(P<0.05);对照组hs-CRP、Hcy水平治疗前后比较,差异无统计学意义(P>0.05)。结论:肾衰宁胶囊治疗维持性血液透析患者疗效显著,在改善肾功能、保护肠黏膜屏障功能及减轻机体微炎症状态方面均具有积极作用。Objective:To observe the effects of Shenshuaining Capsules on intestinal mucosal barrier function and microinflammatory status in patients with maintenance hemodialysis.Methods:A total of 104 cases of patients who had chronic kidney failure and underwent maintenance hemodialysis were selected as the study objects and divided into the control group and the treatment group according to the random number table method,with 52 cases in each group.The control group was treated with maintenance hemodialysis,and the treatment group was additionally treated with Shenshuaining Capsules during the treatment of maintenance hemodialysis.Both groups were treated for three months.Clinical effects,kidney function,intestinal mucosal barrier function and microinflammatory status were compared between the two groups. Results:The total effective rate was 94.23% in the treatment group and 78.85%in the control group,the difference being significant (P<0.05). Before treatment,there was no significantdifference being found in the comparison of the levels of serum creatinine (Scr), blood urea nitrogen(BUN),and estimated glomerular filtration rate (eGFR) between the two groups (P>0.05). After treatment,the levels of Scr and BUN in the treatment group were decreased when compared with those in the samegroup before treatment and those in the control group (P<0.05), and the level of eGFR in the treamentgroup were increased when compared with those in the same group before treatment and those in thecontrol group (P<0.05). There was no significant difference being found in the comparison of the levels ofScr,BUN,and eGFR before and after treatment in the control group (P>0.05). Before treatment,therewas no significant difference being found in the comparison of the levels of D-lactic acid,Endothelin (ET),and diamine oxidase (DAO) between the two groups (P>0.05). After treatment, the levels of D- lacticacid,ET,and DAO in the treatment group were lower than those in the same group before treatment andthose in the control group (P<0.05);there was

关 键 词：慢性肾功能衰竭 维持性血液透析 肾衰宁胶囊 肠黏膜屏障功能 微炎症状态 

分 类 号：R692.5[医药卫生—泌尿科学]