玉屏风颗粒对反复呼吸道感染患儿血清模式识别受体表达的影响  

Effect of Yupingfeng Granules on Serum Pattern Recognition Receptor Expression of Children with Recurrent Respiratory Tract Infection

作　　者：王爱珍[1] 陈妍[1] 方晓丹[1] 王有成[1] WANG Aizhen;CHEN Yan;FANG Xiaodan;WANG Youcheng

机构地区：[1]金华市人民医院儿科,浙江金华321000

出　　处：《新中医》2023年第12期100-104,共5页New Chinese Medicine

基　　金：金华市科学技术研究计划项目(2019-4-043)。

摘　　要：目的:观察玉屏风颗粒对反复呼吸道感染肺脾气虚证患儿血清模式识别受体表达的影响。方法:选取100例反复呼吸道感染肺脾气虚证患儿,按随机数字表法分为常规治疗组和玉屏风治疗组各50例,并选取同期体检的50例健康儿童作为正常对照组。常规治疗组给予细菌溶解产物胶囊治疗,玉屏风治疗组给予玉屏风颗粒治疗,2组均治疗3个月,正常对照组不进行治疗。比较常规治疗组和玉屏风治疗组的临床疗效,以及3组治疗前后血清模式识别受体的表达水平。结果:随访3个月,常规治疗组临床疗效总有效率88.0%,与玉屏风治疗组84.0%比较,差异无统计学意义(P>0.05)。治疗前,常规治疗组与玉屏风治疗组血清Toll样受体1(TLR1)、核苷酸结合寡聚化结构域2(NOD2)、白细胞分化抗原14(CD14)、视黄酸诱导基因蛋白1(RIG1)、C型凝集素受体1(Dectin1)、黑素瘤分化相关基因5(MDA5)蛋白浓度均低于正常对照组(P<0.05)。治疗后,常规治疗组与玉屏风治疗组血清TLR1、CD14、RIG1、Dectin 1、MDA5蛋白浓度均较治疗前升高,且均低于正常对照组(P<0.05);常规治疗组血清NOD2蛋白浓度较治疗前升高,且低于正常对照组(P<0.05);玉屏风治疗组治疗前后血清NOD2蛋白浓度比较,差异无统计学意义(P>0.05);常规治疗组与玉屏风治疗组血清TLR1、NOD2、CD14、RIG1、Dectin 1、MDA5蛋白浓度比较,差异均无统计学意义(P>0.05)。结论:玉屏风颗粒可有效治疗反复呼吸道感染肺脾气虚证患儿,其疗效与细菌溶解产物胶囊相当,可能通过降低血清模式识别受体的表达水平发挥作用。Objective:To observe the effect of Yupingfeng Granules on serum pattern recognition receptor expression of children with recurrent respiratory tract infection with lung-spleen qi deficiency syndrome.Methods:A total of 100 children with recurrent respiratory tract infection with lung-spleen qi deficiency syndrome were selected and divided into the routine treatment group and the Yupingfeng treatment group,with 50 cases in each group,and another 50 cases of healthy children who took health examination at the same period were selected as the normal control group.The routine treatment group was given Bacterial Lysates Capsules for treatment,the Yupingfeng treatment group was treated with Yupingfeng Granules,and the two groups were treated for 3 months.The normal control group was not given any treatments.The clinical effects between the routine treatment group and the Yupingfeng treatment group as well as the expression levels of serum pattern recognition receptor were compared before and after treatment between the 3 groups.Results:After 3 months of follow-up,the total clinicaleffective rate was 88.0%in the routine treatment group and 84.0%in the Yupingfeng treatment group,there being no significant difference(P>0.05).Before treatment,the protein concentration of serum Tolllikereceptor 1(TLR1),nucleotide-binding oligomerization domain-containing protein 2(NOD2),cluster ofdifferentiation 14(CD14),retinoic acid inducible gene 1(RIG1),C-type lectins-1(Dectin 1)and melanomadifferentiation related gene 5(MDA5)in the routine treatment group and the Yupingfeng treatment groupwere lower than those in the normal control group(P<0.05).After treatment,the protein concentration ofserum TLR1,CD14,RIG1,Dectin 1 and MDA5 in the routine treatment group and the Yupingfengtreatment group were increased when compared with those before treatment and lower than those in thenormal control group(P<0.05);the serum NOD2 protein concentration in the routine treatment group wasincreased when compared with that before treatment and was lower t

关 键 词：反复呼吸道感染 儿童 肺脾气虚证 玉屏风颗粒 细菌溶解产物胶囊 血清模式识别受体 

分 类 号：R725.6[医药卫生—儿科]