复方血栓通胶囊联合复方倍他米松治疗口腔扁平苔藓临床研究  

Clinical Study on Compound Xueshuantong Capsules Combined with Compound Betamethasone for Oral Lichen Planus

作　　者：封亚萍 张兵 董斌 FENG Yaping;ZHANG Bing;DONG Bin

机构地区：[1]平顶山市口腔医院儿童牙科,河南平顶山467000 [2]平顶山市口腔医院口腔颌面外科,河南平顶山467000

出　　处：《新中医》2023年第12期110-114,共5页New Chinese Medicine

摘　　要：目的:观察复方血栓通胶囊联合复方倍他米松治疗口腔扁平苔藓的临床疗效及对血清炎症因子水平的影响。方法:按随机数字表法将88例口腔扁平苔藓患者分为对照组和治疗组各44例。对照组采取复方倍他米松治疗,治疗组在对照组基础上联合复方血栓通胶囊治疗。2组疗程均为1个月。比较2组治疗前后症状体征评分、疼痛视觉模拟评分法(VAS)评分、血液流变学指标、炎症因子[白细胞介素-2(IL-2)、白细胞介素-10(IL-10)、肿瘤坏死因子-α(TNF-α)]水平,并分析临床疗效及不良反应情况。结果:治疗组总有效率为97.73%,对照组为84.09%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组症状体征、VAS评分均较治疗前降低(P<0.05),且治疗组症状体征、VAS评分低于对照组(P<0.05)。治疗后,2组血浆黏度、纤维蛋白原、血小板聚集率、红细胞压积水平均较治疗前降低(P<0.05),且治疗组上述各项指标均低于对照组(P<0.05)。治疗后,2组血清IL-2、IL-10、TNF-α水平均较治疗前降低(P<0.05),且治疗组上述各项指标均低于对照组(P<0.05)。治疗组不良反应发生率为4.55%,对照组为11.36%,2组比较,差异无统计学意义(P>0.05)。结论:复方血栓通胶囊联合复方倍他米松治疗口腔扁平苔藓疗效肯定,能有效抑制机体炎症反应,改善患者临床症状体征及血液高黏状态,明显减轻疼痛,且不良反应相对较少。Objective:To observe the curative effect of Compound Xueshuantong Capsules combined with Compound Betamethasone for oral lichen planus and its effect on the levels of serum inflammatory factors.Methods:A total of 88 cases of oral lichen planus patients were divided into the control group and the treatment group according to the random number table method,with 44 cases in each group.The control group was treated with Compound Betamethasone and the treatment group was additionally treated with Compound Xueshuantong Capsules based on the treatment of the control group.Both groups were treated for one month.The scores of symptoms and signs,Visual Analogue Scale(VAS)scores,hemorheology indexes,and levels of inflammatory factors including interleukin-2(IL-2),interleukin-10(IL-10),and tumor necrosis factor-α(TNF-α)were compared before and after treatment between the two groups;clinical effects and adverse reactions were analyzed.Results:The total effective rate was 97.73%in the treatment group and 84.09%in the control group,the difference being significant P<0.05).After treatment,the scores of symptoms,signs,and VAS in the two groups were decreasedwhen compared with those before treatment,and the above scores in the treatment group were lowerthan those in the control group(P<0.05).After treatment,the levels of plasma viscosity,fibrinogen,platelet aggregation rates,and hematocrit in the two groups were decreased when compared with thosebefore treatment(P<0.05),and the above indexes in the treatment group were lower than those in thecontrol group(P<0.05).After treatment,the levels of IL-2,IL-10,and TNF-αin serum in the twogroups were decreased when compared with those before treatment(P<0.05),and the above indexes inthe treatment group were lower than those in the control group(P<0.05).The incidence of adversereactions was 4.55%in the treatment group and 11.36%in the control group,there being no significantdifference between the two groups(P>0.05).Conclusion:Compound Xueshuantong Capsules combinedwith Compound Betameth

关 键 词：口腔扁平苔藓 复方血栓通胶囊 复方倍他米松 炎症因子 

分 类 号：R758.65[医药卫生—皮肤病学与性病学]