沙棘黄酮基于NF-κB通路对哮喘的抑制作用机制的研究进展  

Inhibitory mechanism of seabuckthorn flavonoids on asthma based on NF-κB pathway

作　　者：徐慧 闫莉 张雪松 邓慧明 曹晓东[1] 韩帅(综述)[1] 张子英[1] 张楠[1] 朱晓伟(审校)[1] XU Hui;YAN Li;ZHANG Xuesong;DENG Huiming;CAO Xiaodong;HAN Shuai;ZHANG Ziying;ZAHNG Nan;ZHU Xiaowei(Inner Mongolia Medical University,Hohhot,Inner Mongolia 010110,China)

机构地区：[1]内蒙古医科大学,内蒙古呼和浩特010110

出　　处：《现代医药卫生》2023年第14期2452-2456,共5页Journal of Modern Medicine & Health

基　　金：内蒙古自治区卫生健康科技计划项目(202201180);内蒙古自治区高等学校科学技术研究项目(NJZY22624);内蒙古医科大学青年培育项目(YKD2021QN006);内蒙古医科大学实验室开放基金项目(2022LX01)。

摘　　要：哮喘是气道内慢性炎症性疾病,被肥大细胞、嗜酸粒细胞、T淋巴细胞、B淋巴细胞、巨噬细胞等多种炎症细胞及细胞组分转录调节,产生慢性气道炎、气道高反应及气道重塑。核因子-κB(NF-κB)对炎症级联反应的上游具有调控作用,其过度激活会引起哮喘。黄酮类化合物能有效抑制NF-κB通路的表达,进而减轻炎症反应。沙棘黄酮可通过NF-κB通路对哮喘产生抑制作用。中国沙棘分布面积大、分布种类多,其合理开发对哮喘的治疗具有重要价值。Asthma is a chronic inflammatory disease in the airway,which is regulated by a variety of inflamm atory cells and cell components,like mast cells,eosinophils,T lymphocytes,B lymphocytes,macrophages,and so on,resulting in chronic airway inflammation,airway hyperresponsiveness and airway remodeling.Nuclear factor-κB(NF-κB)plays a regulatory role in the upstream of inflammatory cascade reaction,and its over-activation can cause asthma.Flavonoids can effectively inhibit the expression of NF-κB pathway,further reducing the inflammation.Seabuckthorn flavonoids can inhibit asthma through NF-κB pathway.Seabuckthorn has a large distribution area and many species in China,and its rational development is of great value for asthma treatment.

关 键 词：哮喘 核因子-ΚB 沙棘 黄酮 炎症 综述 

分 类 号：R282.71[医药卫生—中药学] R256.12[医药卫生—中医学]