艾司氯胺酮对术后认知功能障碍影响的研究进展  

Study progress in effect of esketamine on postoperative cognitive dysfunction

作　　者：陶庆宇 朱海娟(综述)[2] 余骏马(审校)[1] TAO Qingyu;ZHU Haijuan;YU Junma(Department of Anesthesiology,Third Affiliated Hospital of Anhui Medical University(Hefei Municipal First People’s Hospital),Hefei,Anhui 230061,China;Department of Anesthesiology,Affiliated Maternal and Child Health Care Hospital of Anhui Medical University,Hefei,Anhui 230001,China)

机构地区：[1]安徽医科大学第三附属医院(合肥市第一人民医院)麻醉科,合肥230061 [2]安徽医科大学附属妇幼保健院麻醉科,合肥230001

出　　处：《重庆医学》2023年第14期2206-2210,共5页Chongqing medicine

基　　金：国家自然科学基金项目(82100315);安徽省卫生健康科研项目(2022[145]号);安徽医科大学临床科学基金项目(2021xkj223)。

摘　　要：艾司氯胺酮作为一种新型的N-甲基-D-天冬氨酸(NMDA)受体拮抗剂,具有镇静、镇痛及促进神经兴奋的作用。术后认知功能障碍(POCD)是麻醉手术后出现的一种中枢神经系统并发症,较为严重者可发展为老年痴呆,是围术期亟待解决的问题。近来研究表明,术中使用艾司氯胺酮可以使手术患者血流动力学更平稳,减少炎性因子的释放,降低POCD的发生率。该文就艾司氯胺酮对POCD影响的研究进展进行阐述,以期为临床提供参考。Esketamine as a new type of N-methyl-D-aspartate(NMDA)receptor antagonist has the roles of sedation,analgesia and promoting the nerve excitation.Postoperative cognitive dysfunction(POCD)is a central nervous system complication after anesthesia operation,more severe cases may develop into senile dementia,which is an urgent problem to be solved in perioperative period.Recent studies have shown that intraoperative use of esketamine could make the surgical patients more stable hemodynamics,reduce the release of inflammatory factors and has the effect for decreasing the incidence rate of POCD.This paper elaborates the study progress of effect of esketamine on POCD in order to provide reference for clinic.

关 键 词：艾司氯胺酮 术后认知功能障碍 神经炎症 

分 类 号：R614[医药卫生—麻醉学]