胰腺术后急性胰腺炎的研究进展  

Advances in the study of postpancreatectomy acute pancreatitis

作　　者：陈昊民 戴梦华 Chen Haomin;Dai Menghua(Department of General Surgery,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,China)

机构地区：[1]中国医学科学院、北京协和医学院、北京协和医院基本外科,北京100730

出　　处：《中华外科杂志》2023年第7期609-613,共5页Chinese Journal of Surgery

摘　　要：胰腺术后急性胰腺炎(PPAP)是多种因素引起的术后早期残胰急性炎症,随着研究的深入,已证实其是术后胰瘘等严重并发症的独立危险因素。少数PPAP进展为坏死性PPAP后会增加患者的死亡风险。国际胰腺外科研究组综合考虑了血清淀粉酶、影像学检查结果、临床影响等因素,将PPAP作为一种独立并发症进行标准化定义和分级。本综述主要回顾了PPAP概念提出历程,总结了其病因、预后、防治相关研究的最新进展。但鉴于相关研究存在较大异质性,且多为回顾性研究,未来有必要提高对PPAP的重视程度,通过更多标准化的研究阐明问题,从而优化胰腺术后并发症的预防与处理。Postpancreatectomy acute pancreatitis(PPAP)is an acute inflammation of the remnant pancreas in the early postoperative period caused by a variety of factors.With the progress of related research,PPAP has been confirmed as an independent risk factor for many severe complications such as postoperative pancreatic fistula.In some cases,it progresses to necrotizing PPAP,increasing the risk of mortality.Currently,the International Study Group for Pancreatic Surgery has standardized and graded PPAP as an independent complication,taking into account factors including serum amylase,radiological features,and clinical impact.This review summarizes how the concept of PPAP was proposed,as well as the latest progress in the research related to its etiology,prognosis,prevention,and treatment.However,given the large heterogeneity of relevant studies and the fact that they were mostly retrospective,in the future,it is necessary to place more emphasis on PPAP and elucidate the problems through more standardized studies to optimize strategies for the prevention and management of complications after pancreatic surgery.

关 键 词：胰腺炎 手术后并发症 术后胰瘘 高淀粉酶血症 胰十二指肠切除术 

分 类 号：R657.51[医药卫生—外科学]