Ocular manifestations and quality of life in patients after hematopoietic stem cell transplantation  

作　　者：Shu-Xian Fan Wen-Hui Wang Peng Zeng Ke-Zhi Huang Yu-Xin Hu Jing Wang Yi-Qing Li Jian-Hui Xiao 

机构地区：[1]Department of Ophthalmology,Sun Yat-sen Memorial Hospital,Sun Yat-sen University,Guangzhou 510120,Guangdong Province,China [2]Department of Hematology,Sun Yat-sen Memorial Hospital,Sun Yat-sen University,Guangzhou 510120,Guangdong Province,China

出　　处：《International Journal of Ophthalmology(English edition)》2023年第7期1138-1144,共7页国际眼科杂志（英文版）

基　　金：Supported by Natural Science Foundation of Guangdong Province,China(No.2019A1515011212);Beijing Bethune Charitable Foundation(No.BJ-GY2021014J)。

摘　　要：AIM:To explore the relationship between ocular and systemic conditions and the impact of ocular complications on the quality of life(QOL)in patients after allogeneic hematopoietic stem cell transplantation(ALLO-HSCT).METHODS:Forty-four patients with severe hematopoietic disease were enrolled after ALLO-HSCT at our center from July 2018 to October 2020.They completed two questionnaires:the Ocular Surface Disease Index(OSDI)and the quality-of-life scale for Chinese patients with visual impairment(SQOL-DV1).Ocular conditions and systemic conditions were also assessed.RESULTS:Eye damage was correlated with total bilirubin(P=0.005),and gamma-glutamyl transferase(GGT)(P=0.021).There was no significant correlation between the overall QOL score and OSDI(P=0.8226)or SQOLDV1(P=0.9526)scores.The OSDI and the overall QOL score were not correlated with ocular conditions,including best-corrected visual acuity(BCVA),intraocular pressure,Schirmer tear test II,sodium fluorescein staining,tear film breakup time,and tear meniscus height.SQOLDV1 was correlated with BCVA(P=0.0007),sodium fluorescein staining(P=0.007),and tear film breakup time(P=0.0146).CONCLUSION:In some patients,early ocular symptoms are not evident after ALLO-HSCT,while ocular surface complications can be observed after a comprehensive ophthalmological examination.Especially for those with elevated total bilirubin or GGT,regular ophthalmic follow-up visits are essential to diagnose and treat ocular graft versus host disease(o GVHD),especially for patients with elevated total bilirubin or GGT.

关 键 词：allogeneic stem cell transplantation ocular graft versus host disease ocular surface disease quality of life quality-of-life scale for Chinese patients with visual impairment Ocular Surface Disease Index 

分 类 号：R457.7[医药卫生—治疗学] R771.3[医药卫生—临床医学]