Significance of age and sex in botulinum neurotoxin dosing for adductor spasmodic dysphonia  

作　　者：Richard Heyes Charles H.Adler Nan Zhang David G.Lott Stephen F.Bansberg 

机构地区：[1]Department of Otorhinolaryngology-Head and Neck Surgery,Mayo Clinic Arizona,Phoenix,Arizona,USA [2]Department of Neurology,Mayo Clinic Arizona,Phoenix,Arizona,USA [3]Department of Biostatistics and Bioinformatics,Mayo Clinic Arizona,Phoenix,Arizona,USA

出　　处：《World Journal of Otorhinolaryngology-Head and Neck Surgery》2023年第2期168-173,共6页世界耳鼻咽喉头颈外科杂志（英文）

摘　　要：Objectives: This study aims to analyze the impact of age and sex on botulinum neurotoxin (BoNT-A) dosing and outcomes in adductor spasmodic dysphonia (AdSD).Methods: A database review of all spasmodic dysphonia patients treated with BoNT from 1989 to 2018 at the Mayo Clinic in Arizona was performed. Only patients who had received ≥4 injections of BoNT-A for AdSD were included. Patients were divided into two cohorts to analyze age, with an age of first treatment cutoff of 60 years. Patients were divided into male and female cohorts to analyze sex.Results: The final analysis included 398 patients. The mean dose of BoNT-A per treatment was significantly higher in the younger cohort (4.4 vs. 3.9 units,p = 0.048). The mean maximal benefit was similar (72% vs. 70%,p = 0.48);however, the mean length of benefit was significantly shorter in younger patients (3.0 vs. 3.6 months,p < 0.01). The mean BoNT-A dose was significantly higher in the female cohort (4.2 vs. 3.6 units,p = 0.02). The mean maximal benefit was similar (69% vs. 75%,p = 0.58), as was the mean length of benefit (3.2 vs. 3.5 months,p = 0.11).Conclusions: This study suggests that age and sex influence BoNT-A dosing and outcomes in AdSD.

关 键 词：ADDUCTOR age GENDER OUTCOMES SEX spasmodic dysphonia 

分 类 号：R767.64[医药卫生—耳鼻咽喉科]