中药复方治疗疼痛的用药规律  

Medication rules of traditional Chinese medicine compounds for pain

作　　者：李心怡 林生 林怡 黄亮晴 谢晓明 田贵华[1] LI Xin-yi;LIN Sheng;LIN Yi;HUANG Liang-qing;XIE Xiao-ming;TIAN Gui-hua(Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China)

机构地区：[1]北京中医药大学东直门医院,北京100700

出　　处：《中国中药杂志》2023年第12期3386-3393,共8页China Journal of Chinese Materia Medica

基　　金：国家中医药管理局青年岐黄学者支持项目(国中医药人教发[2020]7号)。

摘　　要：基于国家知识产权局专利数据库收录的镇痛中药复方为数据来源,整理专利中治疗疼痛的中药复方,探析用药规律,为新型镇痛中药研发提供借鉴。该研究采用IBM SPSS Modeler 18.3、SPSS Statistic 26.0联合对专利数据进行关联规则、聚类分析、复杂网络分析。结果显示,纳入的101首口服方中,使用频次排名前5的中药是甘草、当归、白芍、川芎、丹参;纳入的49首外用方中,使用频次排名前5的药物是没药、乳香、白芷、冰片、川芎。口服方和外用方的药性均以温药为主,且药味均以苦、辛、甘为主。根据中药复杂网络分析,口服方以甘草、当归、白芍、川芎为核心药物,外用方以乳香、没药、甘草、川芎、当归为核心药物。总体而言,口服中药复方多以补气养血、行气活血为主,外用中药复方在口服中药的基础上注重活血化瘀、行气止痛。在未来镇痛药的研发中,可加强安神解郁中药的配伍使用。随着中医药现代化发展,坚持在中医辨证论治思想指导下,基于古法、临床经验方开发新的镇痛中药复方专利,满足当下社会对疼痛治疗的新需求,充分发挥中医药治疗疼痛优势。The present study collected data on traditional Chinese medicine(TCM)compounds effective in relieving pain from the patent database of the State Intellectual Property Office(SIPO),sorted out the TCM compounds against pain in patents,and analyzed the medication rules to provide references for the research and development of new TCM drugs against pain.The data were subjected to frequency statistics,association rules,cluster analysis,and complex network analysis by IBM SPSS Modeler 18.3 and SPSS Statistical 26.0.The results showed that among the 101 oral prescriptions included in the statistics,the top 5 drugs were Glycyrrhizae Radix et Rhizoma,Angelicae Sinensis Radix,Paeoniae Radix Alba,Chuanxiong Rhizoma,and Salviae Miltiorrhizae Radix et Rhizoma,and among the 49 external prescriptions included in the statistics,the top 5 drugs were Myrrha,Olibanum,Angelicae Dahuricae Radix,Borneolum Syntheticum,and Chuanxiong Rhizoma.Whether oral or external prescriptions,the drugs were mainly warm in nature,and bitter,pungent,and sweet in flavor.According to TCM complex network analysis,the core drugs were Glycyrrhizae Radix et Rhizoma,Angelicae Sinensis Radix,Paeoniae Radix Alba,and Chuanxiong Rhizoma in oral prescriptions,and Olibanum,Myrrha,Glycyrrhizae Radix et Rhizoma,Chuanxiong Rhizoma,and Angelicae Sinensis Radix in external prescriptions.Overall,the therapeutic principles of oral prescriptions were mainly replenishing Qi,nourishing blood,and promoting Qi and blood circulation,while those of external prescriptions were activating blood,resolving stasis,promoting Qi flow,and relieving pain on the basis of the oral prescriptions.In the future research and development of TCM compounds against pain,the prescriptions should be modified with mind-tranquilizing and depression-relieving drugs.With the modernization of TCM,the development of new pain-relieving TCM compound patents based on ancient methods and clinical experience adhering to the guidance of TCM treatment based on syndrome differentiation can meet the new demand fo

关 键 词：中药复方 疼痛 用药规律 

分 类 号：R259[医药卫生—中西医结合]