KAP1调控异染色质结构的研究进展  

Research progress in the KAP1 regulating heterochromatin structure

作　　者：郑晓凤 韩明姝 ZHENG Xiao-feng;HAN Ming-shu(College of Bioengineering and Food,Hubei University of Technology,Wuhan 430068,China)

机构地区：[1]湖北工业大学生物工程与食品学院,湖北武汉430068

出　　处：《生物技术》2023年第3期391-396,共6页Biotechnology

摘　　要：KAP1是一种定位于异染色质的脚手架蛋白,调控染色质结构凝集或者松弛。作为异染色质相关蛋白,已发现KAP1与DNA损伤修复、转录,甚至液-液相分离(Liquid-liquid phase separation, LLPS)的形成有密切关系。除此之外,KAP1还参与细胞自噬,促进肿瘤细胞增殖。然而,在这些生理过程中KAP1对异染色质结构的调控及具体机制并不清楚。该文以KAP1蛋白结构及其功能为出发点,总结KAP1在细胞代谢中对异染色质结构的调控作用,为相关研究提供参考。KAPI as a scaffold protein was specifically located on heterochromatin that participates on chromatin agglutination or relaxation.As a heterochromatin associated protein,It has been found that KAP1 plays an important role in DNA damagere pairr and it was also closely related to autophagy,tumor cell growth,transcriptional activation and even the occurrence of LLPS(Liquid-liquid phase separation).However,the regulation and mechanism of KAP1 on heterochromatin structure in these physiological processes are not clear.Therefore,this article takes the structure and function of the KAPl protein,as the starting point to summarize the role of KAP1 in the regulation of heterochromatin structure,and provides a reference for research in related field.

关 键 词：KAP1 异染色质结构 DNA损伤修复 相分离 自噬 逆转录病毒 

分 类 号：Q343.2[生物学—遗传学]