Characterization and antimicrobial,antioxidant,and anti-proliferative activities of green synthesized magnesium oxide nanoparticles with shoot extracts of Plicosepalus curviflorus  

作　　者：Reem Hamoud Alrashoudi Manal Abudawood Ayesha Mateen Hajera Tabassum Noura Ibrahem Alghumlas Sabiha Fatima Basmah Almaarik Farah Maqsood Nawal M.Al Musayeib Musarat Amina 

机构地区：[1]Clinical Laboratory Sciences Department,College of Applied Medical Sciences,King Saud University,Riyadh 12372,Saudi Arabia [2]Department of Optometry and Vision Science,College of Applied Medical Science,King Saud University,Riyadh 11451,Saudi Arabia [3]Department of Pharmacognosy,College of Pharmacy,King Saud University,Riyadh 11495,P.O.Box 22452,Saudi Arabia

出　　处：《Asian Pacific Journal of Tropical Biomedicine》2023年第7期315-324,共10页亚太热带生物医学杂志（英文版）

基　　金：funded by the Researchers Supporting Project Number(RSPD2023R656);King Saud University;Riyadh;Saudi Arabia。

摘　　要：Objective:To synthesize magnesium oxide nanoparticles using ethanol extract of shoots of Plicosepalus curviflorus(PC-MgONPs)and evaluate the antimicrobial,antioxidant,and anti-proliferative activities of PC-MgONPs.Methods:The green synthesized PC-MgONPs were characterized by ultraviolet-visible(UV),Fourier-transform infrared spectroscopy,zeta potential,energy dispersive X-ray,and scanning electron microscopy.Furthermore,we investigated total antioxidant capacity and antimicrobial and anti-proliferative activities using breast cancer cell lines(MDA-231).Results:The UV spectrum of PC-MgONPs showed a sharp absorption peak at 300 nm.The presence of magnesium,oxygen,and sodium was confirmed by energy dispersive X-ray analysis.Scanning electron microscopy revealed PC-MgONPs as roughly spherical granular structures with sizes ranging from 20.0 to 76.4nm.PC-MgONPs showed considerable antimicrobial activities against Escherichia coli,Staphylococcus aureus,methicillin-resistant Staphylococcus aureus,Pseudomonas aeruginosa and Candida albicans with zones of inhibition of 11-17 mm.In addition,total antioxidant capacity and anti-proliferative activity of PC-MgONPs against MDA-231 cells were dose-dependent.Conclusions:The synthesized PC-MgONPs could be a potent antimicrobial,antioxidant and anti-cancer agent,which needs further investigation.

关 键 词：PC-MgONPs Plicosepalus curviflorus FTIR ANTIMICROBIAL Cell viability ANTIOXIDANT 

分 类 号：R285[医药卫生—中药学]