肥胖影响牙周组织再生的机制及治疗策略  

Mechanism of obesity affecting periodontal tissue regeneration and therapeutic strategies

作　　者：陈日新 郑丽纯[1] 李丽丽[1] 李月 闫福华[1] Chen Rixin;Zheng Lichun;Li Lili;Li Yue;Yan Fuhua(Department of Periodontology,Nanjing Stomatological Hospital,Affiliated Hospital of Medical School,Nanjing University,Nanjing 210008,China)

机构地区：[1]南京大学医学院附属口腔医院·南京市口腔医院牙周病科,南京210008

出　　处：《中华口腔医学杂志》2023年第7期686-691,共6页Chinese Journal of Stomatology

基　　金：江苏省重点研发计划社会发展面上项目(BE2022670);江苏省医学重点学科建设单位(JSDW202246)。

摘　　要：肥胖是当今社会面临的重要健康问题,可导致机体处于慢性低水平炎症状态,是高血压、2型糖尿病、非酒精性脂肪性肝病等多种慢性疾病的诱因。牙周炎作为一种常见的口腔慢性感染性疾病,临床上主要表现为牙龈炎症、牙周袋形成、牙槽骨吸收、牙齿松动等。牙周炎治疗的最终目的是实现缺损区域牙周组织的再生。肥胖作为牙周炎的一个重要危险因素,可以通过多种方式影响牙周炎症微环境,最终影响牙周组织再生的效果。因此,本文将从肥胖与牙周组织再生的关系、肥胖影响牙周组织再生的机制、肥胖状态下牙周组织再生的治疗策略等方面进行综述,以期为肥胖状态下牙周组织再生治疗提供新思路。Obesity is an important health problem in our society today,which can lead to the chronic low-grade inflammation state,to be an inducement for many chronic diseases such as hypertension,type 2 diabetes and non-alcoholic fatty liver disease.As a common oral chronic infectious disease,periodontitis is mainly characterized by gingival inflammation,periodontal pocket formation,alveolar bone resorption and tooth mobility.The ultimate goal of periodontitis treatment is to achieve periodontal tissue regeneration in the defect area.As a major risk factor for periodontitis,obesity can alter the periodontal inflammatory microenvironment in multiple ways,affecting the effects of periodontal tissue regeneration ultimately.Therefore,this paper will review the relationship between obesity and periodontal tissue regeneration,mechanism of obesity affecting periodontal tissue regeneration and the therapeutic strategies of periodontal tissue regeneration,providing new ideas for periodontal tissue regeneration treatment in obesity.

关 键 词：肥胖症 牙周炎 牙周微环境 免疫调节 牙周组织再生 

分 类 号：R589.2[医药卫生—内分泌] R781.42[医药卫生—内科学]