中药复方联合外用疗法治疗乳腺增生的研究进展  

Research progress on traditional Chinese medicine compounds combined with external therapy in treatment of hyperplasia of mammary glands

作　　者：管庆霞[1] 杨寒 刘宇萌 李莹 罗煜婷 邹淑君[1] GUAN Qing-xia;YANG Han;LIU Yu-meng;LI Ying;LUO Yu-ting;ZOU Shu-jun(School of Pharmacy,Heilongjiang University of Chinese Medicine,Harbin 150006,China)

机构地区：[1]黑龙江中医药大学药学院,黑龙江哈尔滨150006

出　　处：《中国中药杂志》2023年第11期2856-2867,共12页China Journal of Chinese Materia Medica

基　　金：黑龙江省自然科学基金联合引导项目(LH2022H085);黑龙江省中医药科研项目(ZHY2022-111);黑龙江省教育厅科学技术研究项目(12531624);黑龙江省自然科学基金面上项目(H2016076);哈尔滨市应用技术研究与开发项目(2017RAQXJ090)。

摘　　要：乳腺增生是一种乳腺结构紊乱的良性乳腺疾病,如今乳腺增生在女性群体中发病率逐年上涨,病因与机体的雌激素与孕激素比例失调相关,症状表现为乳房疼痛、乳房结节或乳头溢液,常伴随心理压力使病情逐渐向乳腺癌恶化,因此有必要及时且有效治疗症状。目前中医常用中药口服或外敷、针灸推拿等治疗乳腺增生,西医用抗激素药物或手术治疗。中药能调节激素水平以治疗乳腺增生,针灸等方法能刺激穴位使乳房肿块减小,但传统的中药长期服用可能会产生肝肾毒性,单纯的外部治疗手段见效较慢,很难达到快速有效治疗的效果。西药虽然能够控制病情,但长期服用易产生毒副作用,手术只能切除病灶且复发率高。有研究发现,中药复方内服与外用疗法联用疗效显著,标本兼治,毒副作用小且不良反应少,复发率低。该文整理近年相关文献,就中药复方内服与外治方式并用治疗乳腺增生进行综述,论述其联合疗法的有效性、临床评价指标、作用机制,指出现存不足之处,探索一种值得临床推广应用的综合疗法。Hyperplasia of mammary glands is a benign breast disease with disordered breast structure.Nowadays,the incidence rate of breast hyperplasia in women is increasing year by year,and the etiology is related to the imbalance of estrogen and progesterone in the body.The symptoms include breast pain,breast nodules,or nipple discharge,which can develop into breast cancer in the context of psychological pressure.Therefore,it is timely and effectively necessary for people to treat the symptoms.At present,traditional Chinese medicine(TCM)often treats breast hyperplasia by oral drug,external application,acupuncture,moxibustion,and massage,while western medicine often uses hormone therapy or surgery.TCM can regulate hormone levels to treat breast hyperplasia.Acupuncture,moxibustion,and other methods can stimulate acupoints to reduce breast lumps.However,since TCM is easy to produce hepatorenal toxicity after long-term use and simple external treatment is slow to take effect,rapid and effective treatment is difficult to be achieved.Although western medicine can inhibit the disease,it is easy to produce toxic and side effects if taken for a long time.In addition,surgery can only remove the focus and the recurrence rate is high.Some studies have found that the combination of oral and external use of TCM compounds has a significant effect,with mild toxic and side effects,few adverse reactions,and a low recurrence rate.Based on the relevant literature in recent years,this article reviewed the combination of oral and external treatment of TCM in the treatment of hyperplasia of mammary glands,discussed the effectiveness,clinical evaluation indexes,and mechanism,and pointed out the existing shortcomings to explore a comprehensive therapy worthy of clinical application.

关 键 词：乳腺增生 中药复方 外用疗法 联合治疗 研究进展 

分 类 号：R269[医药卫生—中西医结合]